publication . Article . Other literature type . 2018

Ultrasound molecular imaging of breast cancer in MCF-7 orthotopic mice using gold nanoshelled poly(lactic-co-glycolic acid) nanocapsules: a novel dual-targeted ultrasound contrast agent

Xu,Li; Du,Jing; Wan,Caifeng; Zhang,Yu; Xie,Shaowei; Li,Hongli; Yang,Hong; Li,Fenghua;
  • Published: 01 Mar 2018
  • Publisher: Informa UK Limited
Abstract
Li Xu,1,* Jing Du,1,* Caifeng Wan,1 Yu Zhang,1 Shaowei Xie,1 Hongli Li,1 Hong Yang,2 Fenghua Li1 1Department of Ultrasound, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; 2Department of Chemistry, College of Life and Environmental Science, Shanghai Normal University, Shanghai, China *These authors contributed equally to this work Background: The development of nanoscale molecularly targeted ultrasound contrast agents (UCAs) with high affinity and specificity is critical for ultrasound molecular imaging in the early detection of breast cancer. Purpose: To prospectively evaluate ultrasound molecular imaging with dual-targeted g...
Subjects
free text keywords: International Journal of Nanomedicine, Original Research, ultrasound molecular imaging, targeted ultrasound contrast agent, poly(lactic-co-glycolic acid), antibody, breast cancer, p53, VEGFR2, gold nanoshell, poly (lactic-co-glycolic acid), Medicine (General), R5-920, Biophysics, Organic Chemistry, Bioengineering, Drug Discovery, Biomaterials, General Medicine, MCF-7, Molecular imaging, PLGA, chemistry.chemical_compound, chemistry, Materials science, Biodistribution, In vivo, Molecular biology, Ultrasound, business.industry, business, Flow cytometry, medicine.diagnostic_test, medicine, Nanocapsules
Related Organizations
37 references, page 1 of 3

1. Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin. 2017;67(1):7-30.

2. Ghasemi M, Nabipour I, Omrani A, Alipour Z, Assadi M. Precision medicine and molecular imaging: new targeted approaches toward cancer therapeutic and diagnosis. Am J Nucl Med Mol Imaging. 2016; 6(6):310-327. [OpenAIRE]

3. Chakravarty R, Chakraborty S, Dash A. Molecular imaging of breast cancer: role of RGD Peptides. Mini Rev Med Chem. 2015;15(13): 1073-1094.

4. Anderson CR, Hu X, Zhang H, et al. Ultrasound molecular imaging of tumor angiogenesis with an integrin targeted microbubble contrast agent. Invest Radiol. 2011;46(4):215-224.

5. Kiser J. Molecular imaging and its role in the management of breast cancer. Clin Obstet Gynecol. 2016;59(2):403-411. [OpenAIRE]

6. Funke M. Diagnostic imaging of breast cancer: an update. Radiologe. 2016;56(10):921-938.

7. Abou-Elkacem L, Wilson KE, Johnson SM, et al. Ultrasound molecular imaging of the breast cancer neovasculature using engineered bfironectin scaffold ligands: a novel class of targeted contrast ultrasound agent. Theranostics. 2016;6(11):1740-1752. [OpenAIRE]

8. Yang F, Chen ZY, Lin Y. Advancement of targeted ultrasound contrast agents and their applications in molecular imaging and targeted therapy. Curr Pharm Design. 2013;19(8):1516-1527.

9. Kiessling F, Bzyl J, Fokong S, Siepmann M, Schmitz G, Palmowski M. Targeted ultrasound imaging of cancer: an emerging technology on its way to clinics. Curr Pharm Design. 2012;18(15):2184-2199. [OpenAIRE]

10. Perera RH, Hernandez C, Zhou H, Kota P, Burke A, Exner AA. Ultrasound imaging beyond the vasculature with new generation contrast agents. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015;7(4): 593-608.

11. Lv J-M, Wang X, Marin-Muller C, et al. Current advances in research and clinical applications of PLGA based nanotechnology. Expert Rev Mol Design. 2009;9(4):325-341.

12. Nestor MM, Kei NP, Guadalupe NA, Elisa ME, Adriana GQ, David QG. Preparation and in vitro evaluation of poly(D,L-lactide-co-glycolide) air-filled nanocapsules as a contrast agent for ultrasound imaging. Ultrasonics. 2011;51(7):839-845.

13. Xia K, Zhang L, Huang Y, Lu Z. Preparation of gold nanorods and their applications in photothermal therapy. J Nanosci Nanotechnol. 2015; 15(1):63-73.

14. Kim D, Jeong YY, Jon S. A drug-loaded aptamer-gold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer. ACS Nano. 2010;4(7):3689-3696.

15. Ke H, Wang J, Dai Z, et al. Gold-nanoshelled microcapsules: a theranostic agent for ultrasound contrast imaging and photothermal therapy. Angew Chem Ind Ed Engl. 2011;50(13):3017-3021.

37 references, page 1 of 3
Abstract
Li Xu,1,* Jing Du,1,* Caifeng Wan,1 Yu Zhang,1 Shaowei Xie,1 Hongli Li,1 Hong Yang,2 Fenghua Li1 1Department of Ultrasound, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; 2Department of Chemistry, College of Life and Environmental Science, Shanghai Normal University, Shanghai, China *These authors contributed equally to this work Background: The development of nanoscale molecularly targeted ultrasound contrast agents (UCAs) with high affinity and specificity is critical for ultrasound molecular imaging in the early detection of breast cancer. Purpose: To prospectively evaluate ultrasound molecular imaging with dual-targeted g...
Subjects
free text keywords: International Journal of Nanomedicine, Original Research, ultrasound molecular imaging, targeted ultrasound contrast agent, poly(lactic-co-glycolic acid), antibody, breast cancer, p53, VEGFR2, gold nanoshell, poly (lactic-co-glycolic acid), Medicine (General), R5-920, Biophysics, Organic Chemistry, Bioengineering, Drug Discovery, Biomaterials, General Medicine, MCF-7, Molecular imaging, PLGA, chemistry.chemical_compound, chemistry, Materials science, Biodistribution, In vivo, Molecular biology, Ultrasound, business.industry, business, Flow cytometry, medicine.diagnostic_test, medicine, Nanocapsules
Related Organizations
37 references, page 1 of 3

1. Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin. 2017;67(1):7-30.

2. Ghasemi M, Nabipour I, Omrani A, Alipour Z, Assadi M. Precision medicine and molecular imaging: new targeted approaches toward cancer therapeutic and diagnosis. Am J Nucl Med Mol Imaging. 2016; 6(6):310-327. [OpenAIRE]

3. Chakravarty R, Chakraborty S, Dash A. Molecular imaging of breast cancer: role of RGD Peptides. Mini Rev Med Chem. 2015;15(13): 1073-1094.

4. Anderson CR, Hu X, Zhang H, et al. Ultrasound molecular imaging of tumor angiogenesis with an integrin targeted microbubble contrast agent. Invest Radiol. 2011;46(4):215-224.

5. Kiser J. Molecular imaging and its role in the management of breast cancer. Clin Obstet Gynecol. 2016;59(2):403-411. [OpenAIRE]

6. Funke M. Diagnostic imaging of breast cancer: an update. Radiologe. 2016;56(10):921-938.

7. Abou-Elkacem L, Wilson KE, Johnson SM, et al. Ultrasound molecular imaging of the breast cancer neovasculature using engineered bfironectin scaffold ligands: a novel class of targeted contrast ultrasound agent. Theranostics. 2016;6(11):1740-1752. [OpenAIRE]

8. Yang F, Chen ZY, Lin Y. Advancement of targeted ultrasound contrast agents and their applications in molecular imaging and targeted therapy. Curr Pharm Design. 2013;19(8):1516-1527.

9. Kiessling F, Bzyl J, Fokong S, Siepmann M, Schmitz G, Palmowski M. Targeted ultrasound imaging of cancer: an emerging technology on its way to clinics. Curr Pharm Design. 2012;18(15):2184-2199. [OpenAIRE]

10. Perera RH, Hernandez C, Zhou H, Kota P, Burke A, Exner AA. Ultrasound imaging beyond the vasculature with new generation contrast agents. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015;7(4): 593-608.

11. Lv J-M, Wang X, Marin-Muller C, et al. Current advances in research and clinical applications of PLGA based nanotechnology. Expert Rev Mol Design. 2009;9(4):325-341.

12. Nestor MM, Kei NP, Guadalupe NA, Elisa ME, Adriana GQ, David QG. Preparation and in vitro evaluation of poly(D,L-lactide-co-glycolide) air-filled nanocapsules as a contrast agent for ultrasound imaging. Ultrasonics. 2011;51(7):839-845.

13. Xia K, Zhang L, Huang Y, Lu Z. Preparation of gold nanorods and their applications in photothermal therapy. J Nanosci Nanotechnol. 2015; 15(1):63-73.

14. Kim D, Jeong YY, Jon S. A drug-loaded aptamer-gold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer. ACS Nano. 2010;4(7):3689-3696.

15. Ke H, Wang J, Dai Z, et al. Gold-nanoshelled microcapsules: a theranostic agent for ultrasound contrast imaging and photothermal therapy. Angew Chem Ind Ed Engl. 2011;50(13):3017-3021.

37 references, page 1 of 3
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publication . Article . Other literature type . 2018

Ultrasound molecular imaging of breast cancer in MCF-7 orthotopic mice using gold nanoshelled poly(lactic-co-glycolic acid) nanocapsules: a novel dual-targeted ultrasound contrast agent

Xu,Li; Du,Jing; Wan,Caifeng; Zhang,Yu; Xie,Shaowei; Li,Hongli; Yang,Hong; Li,Fenghua;