publication . Article . 2018

Isolation and Characterization of Neural Crest-Derived Stem Cells From Adult Ovine Palatal Tissue

Sokratis Stergiadis; Darius Widera; Wolf Grimm;
Open Access
  • Published: 01 Apr 2018 Journal: Frontiers in Cell and Developmental Biology, volume 6 (eissn: 2296-634X, Copyright policy)
  • Publisher: Frontiers Media SA
  • Country: United Kingdom
Adult mammalian craniofacial tissues contain limited numbers of post-migratory neural crest-derived stem cells. Similar to their embryonic counterparts, these adult multipotent stem cells can undergo multi-lineage differentiation and are capable of contributing to regeneration of mesodermal and ectodermal cells and tissues in vivo. In the present study, we describe for the first time the presence of Nestin-positive neural crest-derived stem cells (NCSCs) within the ovine hard palate. We show that these cells can be isolated from the palatal tissue and are able to form neurospheres. Ovine NCSCs express the typical neural crest markers Slug and Twist, exhibit high...
Medical Subject Headings: embryonic structuresanimal structures
free text keywords: neural crest-derived stem cells, neural crest, multipotency, ovine stem cells, large animal model, Biology (General), QH301-705.5
Related Organizations
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