publication . Conference object . 2007

Clustering of individuals given SNPs similarity based on normalized mutual information: F7 SNPs in the GAIT sample

Montserrat Vallverdú; Maria Sabater-Lleal; José Manuel Soria; J. C. Souto; L. Pattini; Jordi Fontcuberta; M.C. Di Bernardo; Alfonso Buil; Alexandre Perera; Pere Caminal;
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  • Published: 23 Oct 2007 Journal: 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (issn: 1557-170X, Copyright policy)
  • Publisher: IEEE
Abstract
This paper proposes the clustering of individuals given their genotype using a normalized Mutual Information dissimilarity distance. This method is applied to a Single Nucleotyde Polymorphism set belonging to F7 gene, uncovering the intrinsic genetic variability on one Spanish population. This genetic variability corresponds to results published using a complete different approach in population genetics literature. Identified groups are shown to express significant differences in the level of FVII concentration.
Subjects
free text keywords: Gait, Normalized mutual information, Population genetics, Genotype, Single-nucleotide polymorphism, Genetics, Genetic variability, Statistics, Cluster analysis, Polymorphism (computer science), Biology
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