publication . Article . 2017

Ultrastructural Analysis of Pseudorabies Virus Infection in IB-RS-2 Cell Line and with Treatment by Persea americana Extract

Isabela Cristina Simoni; Joaquim Moraes de Oliveira; Ana Paula de Almeida; Sônia Soares Costa;
Open Access
  • Published: 31 Aug 2017 Journal: International Journal of Environmental and Agriculture Research, volume 3, pages 36-43 (eissn: 2454-1850, Copyright policy)
  • Publisher: AD Publications
In this study, we focused on the cycle of replication of the Pseudorabies virus (PrV) in the swine IB-RS-2 cell line in absence or in presence of an infusion from Persea americana leaves. The ultrastructure of the Nova Prata strain virus presents the typical characteristics of Varicelovirus as well as lytic replication with total cell destruction between 18 and 24 hours post-infection (pi). Adsorption is immediate followed by fusion penetration of the virus membranes with those of the host. The capsid once inside the cell migrates to the nucleus where it disappears. Precursor viral particles appear from 4 hours and will form the nuclear crystalloids. The capsids...
Medical Subject Headings: viruses
free text keywords: Viral envelope, Virus, Molecular biology, Virology, Pseudorabies, biology.organism_classification, biology, Chemistry, Lytic cycle, Cell culture, Cell, medicine.anatomical_structure, medicine, Viral replication, Cytoplasm
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