publication . Article . Other literature type . 2007

TRAF1–C5 as a Risk Locus for Rheumatoid Arthritis — A Genomewide Study

Daniel L. Kastner; Annette T. Lee; Sven Pettersson; Houman Khalili; Evan Beckman; Lindsey A. Criswell; Anbupalam Thalamuthu; Anthony Liew; Leela Davies; Mark Seielstad; ...
Open Access
  • Published: 20 Sep 2007 Journal: New England Journal of Medicine, volume 357, pages 1,199-1,209 (issn: 0028-4793, eissn: 1533-4406, Copyright policy)
  • Publisher: Massachusetts Medical Society
Abstract
A B S T R AC T Background Rheumatoid arthritis has a complex mode of inheritance. Although HLA-DRB1 and PTPN22 are well-established susceptibility loci, other genes that confer a modest level of risk have been identified recently. We carried out a genomewide association analysis to identify additional genetic loci associated with an increased risk of rheu- matoid arthritis. Methods We genotyped 317,503 single-nucleotide polymorphisms (SNPs) in a combined case- control study of 1522 case subjects with rheumatoid arthritis and 1850 matched con - trol subjects. The patients were seropositive for autoantibodies against cyclic citrul- linated peptide (CCP). We obtain...
Subjects
Medical Subject Headings: musculoskeletal diseases
free text keywords: Article, Arthritis, medicine.disease, medicine, PTPN22, Rheumatoid arthritis, Case-control study, Single-nucleotide polymorphism, Linkage disequilibrium, Immunology, business.industry, business, Risk factor, Locus (genetics)
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