publication . Other literature type . Article . 1974

On Some Principles Governing Molecular Evolution*

Kimura M.; Ohta T.;
Open Access English
  • Published: 01 Jul 1974
Abstract
Abstract The following five principles were deduced from the accumulated evidence on molecular evolution and theoretical considerations of the population dynamics of mutant substitutions: (i) for each protein, the rate of evolution in terms of amino acid substitutions is approximately constant/site per year for various lines, as long as the function and tertiary structure of the molecule remain essentially unaltered. (ii) Functionally less important molecules or parts of a molecule evolve (in terms of mutant substitutions) faster than more important ones. (iii) Those mutant substitutions that disrupt less the existing structure and function of a molecule (conser...
Subjects
free text keywords: Biological Sciences: Genetics, Multidisciplinary, Molecular evolution, Rate of evolution, Genetics, Gene, Mutation, medicine.disease_cause, medicine, Protein tertiary structure, Biology, Mutant, Gene duplication, Population, education.field_of_study, education
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publication . Other literature type . Article . 1974

On Some Principles Governing Molecular Evolution*

Kimura M.; Ohta T.;