publication . Article . 2016

Visualisation of Kiss1 Neurone Distribution Using a Kiss1-CRE Transgenic Mouse.

Yeo, S.‐H.; Kyle, V.; Morris, P. G.; Jackman, S.; Sinnett‐Smith, L. C.; Schacker, M.; Chen, C.; Colledge, W. H.;
Open Access
  • Published: 28 Oct 2016 Journal: Journal of Neuroendocrinology, volume 28 (issn: 0953-8194, Copyright policy)
  • Publisher: Wiley
Kisspeptin neuropeptides are encoded by the Kiss1 gene and play a critical role in the regulation of the mammalian reproductive axis. Kiss1 neurones are found in two locations in the rodent hypothalamus: one in the arcuate nucleus (ARC) and another in the RP3V region, which includes the anteroventral periventricular nucleus (AVPV). Detailed mapping of the fibre distribution of Kiss1 neurones will help with our understanding of the action of these neurones in other regions of the brain. We have generated a transgenic mouse in which the Kiss1 coding region is disrupted by a CRE‐GFP transgene so that expression of the CRE recombinase protein is driven from the Kiss...
Medical Subject Headings: nervous system
free text keywords: Anteroventral periventricular nucleus, Hypothalamus, Kisspeptin, Nucleus, medicine.anatomical_structure, medicine, Amygdala, Lateral hypothalamus, Neuropeptide, Internal medicine, medicine.medical_specialty, Biology, Transgene, Endocrinology, Original Article, Original Articles, Kiss‐CRE, transgenic, mouse, tdTomato, CLARITY, neuronal distribution
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publication . Article . 2016

Visualisation of Kiss1 Neurone Distribution Using a Kiss1-CRE Transgenic Mouse.

Yeo, S.‐H.; Kyle, V.; Morris, P. G.; Jackman, S.; Sinnett‐Smith, L. C.; Schacker, M.; Chen, C.; Colledge, W. H.;