publication . Article . Other literature type . 2015

Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patients

Philippe Chanson;
  • Published: 17 Jul 2015
CONTEXT: Despite being a classical growth disorder, pituitary gigantism has not been studied previously in a standardized way. OBJECTIVE: To characterize a large series of pituitary gigantism patients. DESIGN: Retrospective, multicenter, international study. SETTING: Tertiary referral hospital outpatients departments PATIENTS: 208 patients (163 males;78.4%) with growth hormone excess and current/previous abnormal growth velocity for age or final height >2SD above country normal means. 143 patients consented to genetic analyses. MAIN OUTCOME MEASURES: Growth, hormonal and symptomatic measures at baseline and during management RESULTS: Median onset of rapid growth...
free text keywords: Article, Pituitary Gigantism, Biology, Growth velocity, Endocrinology, medicine.medical_specialty, medicine, Pituitary adenoma, medicine.disease, Male predominance, Gigantism, Young adult, Internal medicine, Disease control, Genetic etiology
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