publication . Article . Other literature type . 2018

Calcium signalling in exocrine pancreas

Julia Gerasimenko; Oleg Gerasimenko; Ole Petersen;
Open Access English
  • Published: 01 Jul 2018
  • Publisher: Wiley
  • Country: United Kingdom
Key points Ca2+ signalling in different cell types in exocrine pancreatic lobules was monitored simultaneously and signalling responses to various stimuli were directly compared.Ca2+ signals evoked by K+‐induced depolarization were recorded from pancreatic nerve cells. Nerve cell stimulation evoked Ca2+ signals in acinar but not in stellate cells.Stellate cells are not electrically excitable as they, like acinar cells, did not generate Ca2+ signals in response to membrane depolarization.The responsiveness of the stellate cells to bradykinin was markedly reduced in experimental alcohol‐related acute pancreatitis, but they became sensitive to stimulation with tryp...
free text keywords: Research Paper, Special section: Intracellular calcium signalling, Editor's Choice, calcium signalling, exocrine pancreas, pancreatitis, Physiology
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