publication . Article . Other literature type . 1998

Clinical safety of a polyvalent F(ab′)2 equine antivenom in 223 African snake envenomations: a field trial in Cameroon

Chippaux, Jean-Philippe; Lang, J.; Amadi Eddine, S; Fagot, P.; Rage, V.; Peyrieux, J.C.; Le Mener, V.;
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  • Published: 01 Jan 1998 Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene, volume 92, pages 657-662 (issn: 0035-9203, Copyright policy)
  • Publisher: Oxford University Press (OUP)
  • Country: United States
Abstract
A large-scale clinical trial was conducted, according to World Health Organization Good Clinical Practice guidelines, in 7 centres in North Cameroon to determine the safety and efficacy of a polyvalent antivenom composed of purified F(ab')2. This study included 223 patients presenting clinically with an obvious snake bite, predominantly due to #Echis ocellatus$ (viper), the most abundant species in this savannah region. Clinical surveillance was maintained for 5 d in all patients and until the twenty-sixth day in 74% of cases. Two 10 mL ampoules of polyvalent F(ab')2 equine antivenom (Ipser Africa (TM)) were administered to each patient by intravenous infusion. ...
Subjects
free text keywords: ESSAI CLINIQUE, TRAITEMENT MEDICAL, EFFICACITE, VENIN, SERPENT, ENVENIMATION, SEROTHERAPIE, PROTOCOLE D'UTILISATION, EFFET SECONDAIRE, Anaphylaxis, medicine.disease, medicine, Surgery, medicine.medical_specialty, Infusion Procedure, business.industry, business, Envenomation, Clinical trial, Serum sickness, Immunology, Anesthesia, Snake bites, Case fatality rate, Antivenom
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