publication . Other literature type . Article . 2009

Multilocus analysis of age-related macular degeneration.

Bergeron-Sawitzke, Julie; Gold, Bert; Olsh, Adam; Schlotterbeck, Sarah; Lemon, Kendal; Visvanathan, Kala; Allikmets, Rando; Dean, Michael;
Open Access English
  • Published: 04 Mar 2009
  • Publisher: Nature Publishing Group
Abstract
Age-related macular degeneration (AMD) is a late onset vision disorder. Recent studies demonstrate that alterations in complement cascade genes are associated with AMD. Of the three identified complement loci, variants in complement factor H (CFH) have the highest impact as does an independent locus at 10q26. Our matched case–control study using the Age-Related Eye Disease Study (AREDS) cohort confirms and extends the associations in these loci. Subjects were genotyped for single nucleotide polymorphisms (SNPs) from CFH, complement component 2 (C2), complement component 3 (C3), complement factor B (CFB), age-related maculopathy susceptibility (ARMS2), HtrA serin...
Subjects
Medical Subject Headings: eye diseases
free text keywords: Article, Genetics(clinical), Genetics, Complement component 2, Complement system, Allele frequency, Single-nucleotide polymorphism, Factor H, Biology, Population, education.field_of_study, education, Complement component 3, Complement factor B
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