A significant number of anthropogenic organic micropollutants are classified as hardly- or non-biodegradable compounds, which may adversely affect on living organisms, including human health. Municipal wastewater and wastewater from various industry sectors are considered as the main source of this type of pollutants. The aim of the conducted study was to develop a method for the removal of selected micropollutants such as diclofenac, octylphenol, anthracene and benzo[a]pyrene from various water streams based on advanced oxidation processes and membrane filtration techniques. The research was carried out on solutions prepared based on deionised water and a model real and real effluent from a mechanical-biological wastewater treatment line. The concentration of micropollutions was 0.5 mg/dm3. Photocatalytic oxidation was applied in the presence of TiO2 in a batch reactor equipped with a UV lamp of 150 W. The post-processing solutions ware subjected to the ultrafiltration process, which allowed for the separation of catalyst particles and the retention of high molecular weight organic compounds occurring in the treated water streams. The membrane filtration process was operated in a dead-end mode at a transmembrane pressure of 2 MPa. For their complete elimination, the second stage of membrane filtration using a nanofiltration membrane was applied. The chromatographic analysis, performed to determine the removal degree of tested micropollutants in the post-processing solutions, indicated their incomplete decomposition in the photocatalysis process and the generation of a significant number of their oxidation by-products. The proposed sequential system, that combines photocatalysis with two-stage membrane filtration, allowed for over 91% removal of micropollutants from water solutions prepared on the basis of deionised water and for a complete removal of the compounds and their oxidation by-products from model and real wastewater effluents.