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Role of Eukaryotic Initiation Factors during Cellular Stress and Cancer Progression

Authors: Divya Khandige Sharma; Kamiko R. Bressler; Harshil Patel; Nirujah Balasingam; Nehal Thakor;

Role of Eukaryotic Initiation Factors during Cellular Stress and Cancer Progression

Abstract

Protein synthesis can be segmented into distinct phases comprising mRNA translation initiation, elongation, and termination. Translation initiation is a highly regulated and rate-limiting step of protein synthesis that requires more than 12 eukaryotic initiation factors (eIFs). Extensive evidence shows that the transcriptome and corresponding proteome do not invariably correlate with each other in a variety of contexts. In particular, translation of mRNAs specific to angiogenesis, tumor development, and apoptosis is altered during physiological and pathophysiological stress conditions. In cancer cells, the expression and functions of eIFs are hampered, resulting in the inhibition of global translation and enhancement of translation of subsets of mRNAs by alternative mechanisms. A precise understanding of mechanisms involving eukaryotic initiation factors leading to differential protein expression can help us to design better strategies to diagnose and treat cancer. The high spatial and temporal resolution of translation control can have an immediate effect on the microenvironment of the cell in comparison with changes in transcription. The dysregulation of mRNA translation mechanisms is increasingly being exploited as a target to treat cancer. In this review, we will focus on this context by describing both canonical and noncanonical roles of eIFs, which alter mRNA translation.

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Subjects by Vocabulary

Library of Congress Subject Headings: lcsh:QH426-470 lcsh:Biochemistry lcsh:Genetics lcsh:QD415-436

Microsoft Academic Graph classification: Cell Translation (biology) EIF4A1 Biology Eukaryotic translation initiation factor 4 gamma Cell biology Transcriptome Eukaryotic translation medicine.anatomical_structure Eukaryotic initiation factor Protein biosynthesis medicine

Keywords

Review Article, Biochemistry, Molecular Biology

184 references, page 1 of 19

Holcik, M., Sonenberg, N.. Translational control in stress and apoptosis. Nature Reviews Molecular Cell Biology . 2005; 6 (4): 318-327 [OpenAIRE] [PubMed] [] [DOI]

Tebaldi, T., Re, A., Viero, G.. Widespread uncoupling between transcriptome and translatome variations after a stimulus in mammalian cells. BMC Genomics . 2012; 13, article 220 [OpenAIRE] [] [DOI]

Schwanhüusser, B., Busse, D., Li, N.. Global quantification of mammalian gene expression control. Nature . 2011; 473 (7347): 337-342 [OpenAIRE] [PubMed] [] [DOI]

Bhat, M., Robichaud, N., Hulea, L., Sonenberg, N., Pelletier, J., Topisirovic, I.. Targeting the translation machinery in cancer. Nature Reviews Drug Discovery . 2015; 14 (4): 261-278 [OpenAIRE] [PubMed] [] [DOI]

Kong, J., Lasko, P.. Translational control in cellular and developmental processes. Nature Reviews Genetics . 2012; 13 (6): 383-394 [OpenAIRE] [PubMed] [] [DOI]

Ruggero, D.. Translational control in cancer etiology. Cold Spring Harbor Perspectives in Biology . 2013; 5 (2) [OpenAIRE] [PubMed] [] [DOI]

Silvera, D., Formenti, S. C., Schneider, R. J.. Translational control in cancer. Nature Reviews Cancer . 2010; 10 (4): 254-266 [OpenAIRE] [PubMed] [] [DOI]

Thakor, N., Holcik, M.. IRES-mediated translation of cellular messenger RNA operates in eIF2α-independent manner during stress. Nucleic Acids Research . 2012; 40 (2): 541-552 [OpenAIRE] [PubMed] [] [DOI]

Leprivier, G., Rotblat, B., Khan, D., Jan, E., Sorensen, P. H.. Stress-mediated translational control in cancer cells. Biochimica et Biophysica Acta (BBA)—Gene Regulatory Mechanisms . 2015; 1849 (7): 845-860 [OpenAIRE] [PubMed] [] [DOI]

Fonseca, B. D., Zakaria, C., Jia, J.-J.. La-related protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1). The Journal of Biological Chemistry . 2015; 290 (26): 15996-16020 [OpenAIRE] [PubMed] [] [DOI]

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  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    55
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
55
Top 10%
Top 10%
Top 10%
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