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Stochastic Modeling of an Infectious Disease, Part I: Understand the Negative Binomial Distribution and Predict an Epidemic More Reliably

Authors: Kobayashi, Hisashi;

Stochastic Modeling of an Infectious Disease, Part I: Understand the Negative Binomial Distribution and Predict an Epidemic More Reliably

Abstract

Why are the epidemic patterns of COVID-19 so different among different cities or countries which are similar in their populations, medical infrastructures, and people's behavior? Why are forecasts or predictions made by so-called experts often grossly wrong, concerning the numbers of people who get infected or die? The purpose of this study is to better understand the stochastic nature of an epidemic disease, and answer the above questions. Much of the work on infectious diseases has been based on "SIR deterministic models," (Kermack and McKendrick:1927.) We will explore stochastic models that can capture the essence of the seemingly erratic behavior of an infectious disease. A stochastic model, in its formulation, takes into account the random nature of an infectious disease. The stochastic model we study here is based on the "birth-and-death process with immigration" (BDI for short), which was proposed in the study of population growth or extinction of some biological species. The BDI process model ,however, has not been investigated by the epidemiology community. The BDI process is one of a few birth-and-death processes, which we can solve analytically. Its time-dependent probability distribution function is a "negative binomial distribution" with its parameter $r$ less than $1$. The "coefficient of variation" of the process is larger than $\sqrt{1/r} > 1$. Furthermore, it has a long tail like the zeta distribution. These properties explain why infection patterns exhibit enormously large variations. The number of infected predicted by a deterministic model is much greater than the median of the distribution. This explains why any forecast based on a deterministic model will fail more often than not.

28 pages, 14 figures

Keywords

Methodology (stat.ME), FOS: Computer and information sciences, J.3, FOS: Biological sciences, G.3; I.6; J.3, G.3, Populations and Evolution (q-bio.PE), Quantitative Biology - Populations and Evolution, I.6, 00, Statistics - Methodology

27 references, page 1 of 3

[1] H. Kobayashi, \Stochastic Modeling of an Infectious Disease: Part II: Validation by Simulation Experiments (under preparation)." http://hp.hisashikobayashi.com, 2020.

[2] W. O. Kermack and A. G. McKendrick, \A Contribution to the Mathematical Theory of Epidemics," Proc. Royal Soc. London, vol. A 115, pp. 700{721, 1927.

[3] N. Bacaer, \The model of Kermack and McKendrick for the plague epidemic in Bombay and the type reproduction number with seasonality," Journals of Mathematical Biology, vol. 64, pp. 403{422, March 2012.

[4] R. M. Anderson and R. M. May, \Population Biology of Infectious Diseases: Part I," Nature, vol. 280, pp. 361{367, August 1979.

[5] R. M. Anderson and R. M. May, Infectious Diseases of Humans: Dynamics and Control. Oxford University Press, 1991.

[6] M. Martcheva, An Introduction to Mathematical Epidemiology. Springer, 2010.

[7] W. Feller, \Die Grundlagen der Volterraschen Theorie des Kampfes ums Dasein in wahrscheinlichkeitstheoritischer Behandlung," Acta Biotheoretica, vol. 5, pp. 11{40, 1939. [OpenAIRE]

[8] D. G. Kendall, \The generalized \birth-and-death" process," Ann. Math. Statist., vol. 19, pp. 1{15, 1948.

[9] W. Feller, Introduction to Probability and Its Applications: Vol. I. John Wiley & Sons, 1968.

[10] R. Syski, Introduction to Congestion Theory in Telephone Systems. North Holland, 1986.

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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