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Automatic temporal lobe atrophy assessment in prodromal AD: Data from the DESCRIPA study
Copyright policy )Automatic temporal lobe atrophy assessment in prodromal AD: Data from the DESCRIPA study
AbstractBackgroundIn the framework of the clinical validation of research tools, this investigation presents a validation study of an automatic medial temporal lobe atrophy measure that is applied to a naturalistic population sampled from memory clinic patients across Europe.MethodsThe procedure was developed on 1.5‐T magnetic resonance images from the Alzheimer's Disease Neuroimaging Initiative database, and it was validated on an independent data set coming from the DESCRIPA study. All images underwent an automatic processing procedure to assess tissue atrophy that was targeted at the hippocampal region. For each subject, the procedure returns a classification index. Once provided with the clinical assessment at baseline and follow‐up, subjects were grouped into cohorts to assess classification performance. Each cohort was divided into converters (co) and nonconverters (nc) depending on the clinical outcome at follow‐up visit.ResultsWe found the area under the receiver operating characteristic curve (AUC) was 0.81 for all co versus nc subjects, and AUC was 0.90 for subjective memory complaint (SMCnc) versus all co subjects. Furthermore, when training on mild cognitive impairment (MCI‐nc/MCI‐co), the classification performance generally exceeds that found when training on controls versus Alzheimer's disease (CTRL/AD).ConclusionsAutomatic magnetic resonance imaging analysis may assist clinical classification of subjects in a memory clinic setting even when images are not specifically acquired for automatic analysis.
- Lund University Sweden
- Maastricht University Netherlands
- University of Eastern Finland Finland
- University of Genoa Italy
- Amsterdam UMC - Vrije Universiteit Amsterdam Netherlands
Microsoft Academic Graph classification: Audiology education.field_of_study medicine.diagnostic_test Cohort Psychology medicine.medical_specialty Population Temporal lobe Atrophy Neuroimaging medicine Psychiatry education Receiver operating characteristic Memory clinic Magnetic resonance imaging medicine.disease
Male, Databases, Factual, Epidemiology, Image Processing, Hippocampus, Image analysis, Computer-Assisted, 80 and over, Image Processing, Computer-Assisted, Memory clinics, Aged, 80 and over, Health Policy, Alzheimer's disease, Magnetic Resonance Imaging, Temporal Lobe, Psychiatry and Mental health, Medial temporal lobe, Female, MRI, Mild Cognitive Impairment, Prodromal Symptoms, Alzheimer's disease; Hippocampus; Image analysis; Medial temporal lobe; Memory clinics; MRI; Naturalistic population; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Databases, Factual; Female; Follow-Up Studies; Hippocampus; Humans; Image Processing, Computer-Assisted; Male; Mental Status Schedule; Mild Cognitive Impairment; Reproducibility of Results; Temporal Lobe; Magnetic Resonance Imaging; Prodromal Symptoms; Neurology (clinical); Developmental Neuroscience; Cellular and Molecular Neuroscience; Psychiatry and Mental Health; Geriatrics and Gerontology; Epidemiology; Health Policy, Databases, Cellular and Molecular Neuroscience, Developmental Neuroscience, Alzheimer Disease, Humans, Cognitive Dysfunction, Factual, Aged, Reproducibility of Results, Naturalistic population, Neurology (clinical), Atrophy, Geriatrics and Gerontology, Mental Status Schedule, Follow-Up Studies
Male, Databases, Factual, Epidemiology, Image Processing, Hippocampus, Image analysis, Computer-Assisted, 80 and over, Image Processing, Computer-Assisted, Memory clinics, Aged, 80 and over, Health Policy, Alzheimer's disease, Magnetic Resonance Imaging, Temporal Lobe, Psychiatry and Mental health, Medial temporal lobe, Female, MRI, Mild Cognitive Impairment, Prodromal Symptoms, Alzheimer's disease; Hippocampus; Image analysis; Medial temporal lobe; Memory clinics; MRI; Naturalistic population; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Databases, Factual; Female; Follow-Up Studies; Hippocampus; Humans; Image Processing, Computer-Assisted; Male; Mental Status Schedule; Mild Cognitive Impairment; Reproducibility of Results; Temporal Lobe; Magnetic Resonance Imaging; Prodromal Symptoms; Neurology (clinical); Developmental Neuroscience; Cellular and Molecular Neuroscience; Psychiatry and Mental Health; Geriatrics and Gerontology; Epidemiology; Health Policy, Databases, Cellular and Molecular Neuroscience, Developmental Neuroscience, Alzheimer Disease, Humans, Cognitive Dysfunction, Factual, Aged, Reproducibility of Results, Naturalistic population, Neurology (clinical), Atrophy, Geriatrics and Gerontology, Mental Status Schedule, Follow-Up Studies
Microsoft Academic Graph classification: Audiology education.field_of_study medicine.diagnostic_test Cohort Psychology medicine.medical_specialty Population Temporal lobe Atrophy Neuroimaging medicine Psychiatry education Receiver operating characteristic Memory clinic Magnetic resonance imaging medicine.disease
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).18 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).18 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!- Canadian Institutes of Health Research (CIHR)
- Lund University Sweden
- Maastricht University Netherlands
- University of Eastern Finland Finland
- University of Genoa Italy
- Amsterdam UMC - Vrije Universiteit Amsterdam Netherlands
- Vrije Universiteit Amsterdam Netherlands
- Heidelberg University Germany
- Malmö University Sweden
- University of Bari Aldo Moro Italy
- Kuopio University Hospital Finland
- National Institute for Nuclear Physics Italy
AbstractBackgroundIn the framework of the clinical validation of research tools, this investigation presents a validation study of an automatic medial temporal lobe atrophy measure that is applied to a naturalistic population sampled from memory clinic patients across Europe.MethodsThe procedure was developed on 1.5‐T magnetic resonance images from the Alzheimer's Disease Neuroimaging Initiative database, and it was validated on an independent data set coming from the DESCRIPA study. All images underwent an automatic processing procedure to assess tissue atrophy that was targeted at the hippocampal region. For each subject, the procedure returns a classification index. Once provided with the clinical assessment at baseline and follow‐up, subjects were grouped into cohorts to assess classification performance. Each cohort was divided into converters (co) and nonconverters (nc) depending on the clinical outcome at follow‐up visit.ResultsWe found the area under the receiver operating characteristic curve (AUC) was 0.81 for all co versus nc subjects, and AUC was 0.90 for subjective memory complaint (SMCnc) versus all co subjects. Furthermore, when training on mild cognitive impairment (MCI‐nc/MCI‐co), the classification performance generally exceeds that found when training on controls versus Alzheimer's disease (CTRL/AD).ConclusionsAutomatic magnetic resonance imaging analysis may assist clinical classification of subjects in a memory clinic setting even when images are not specifically acquired for automatic analysis.