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Long term persistence of coronavirus SARS-CoV-2 infection
Copyright policy )Long term persistence of coronavirus SARS-CoV-2 infection
ABSTRACT During the COVID-19 pandemic, a case of a long-term persistence of SARS-CoV-2 infection (from March 26 to May 20, 2020) was identified at a private hospital in São Paulo, SP, Brazil. The long-term positivity for SARS-CoV-2 in reverse transcriptase polymerase chain reaction tests of a patient diagnosed with COVID-19 suggests, at least part of patients who recovered, may still carry and transmit the SARS-CoV-2 virus. This fact emphasizes the importance of having at least two negative reverse transcriptase polymerase chain reaction test results for SARS-CoV-2. Serological assays were not particularly helpful in the case described, since the patient had very low antibodies titers at the end of the follow-up period. Low viral loads may not be detected by current molecular methods, leading to wrong conclusions regarding viral clearance.
Medical Subject Headings: viruses virus diseases
Microsoft Academic Graph classification: Virus law.invention Persistence (computer science) law Pandemic Medicine Polymerase chain reaction Polymerase biology business.industry Virology Long term persistence Reverse transcriptase biology.protein Severe acute respiratory syndrome coronavirus business
COVID-19o, Relato De Caso, Case Report, Infecções por coronavírus, SARS-CoV-2, Infecções Coronavírus, R, COVID-19, General Medicine, Coronavírus, Medicine
COVID-19o, Relato De Caso, Case Report, Infecções por coronavírus, SARS-CoV-2, Infecções Coronavírus, R, COVID-19, General Medicine, Coronavírus, Medicine
Medical Subject Headings: viruses virus diseases
Microsoft Academic Graph classification: Virus law.invention Persistence (computer science) law Pandemic Medicine Polymerase chain reaction Polymerase biology business.industry Virology Long term persistence Reverse transcriptase biology.protein Severe acute respiratory syndrome coronavirus business
1. She J, Jiang J, Ye L, Hu L, Bai C, Song Y. 2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies. Clin Transl Med. 2020;9(1):19. Review.
2. World Health Organization (WHO). WHO Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. Geneva: WHO; 2020 [cited 2020 Feb 12]. Available from: https://www.who.int/dg/speeches/ detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncovon-11-february-2020
3. World Health Organization (WHO). Novel Coronavirus (2019-nCoV): situation report - 10. Geneva: WHO; 2020 [cited 2020 Feb 2]. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/ 20200130-sitrep-10-ncov.pdf?sfvrsn=d0b2e480_2
4. Sifuentes-Rodríguez E, Palacios-Reyes D. COVID-19: the outbreak caused by a new coronavirus. Bol Med Hosp Infant Mex. 2020;77(2):47-53. Review.
5. Shaker MS, Oppenheimer J, Grayson M, Stukus D, Hartog N, Hsieh EW, et al. COVID-19: pandemic contingency planning for the allergy and immunology clinic. J Allergy Clin Immunol Pract. 2020;8(5):1477-88.e5. Review.
6. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DS, Du B, Li LJ, Zeng G, Yuen KY, Chen RC, Tang CL, Wang T, Chen PY, Xiang J, Li SY, Wang JL, Liang ZJ, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Chen Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Zhong NS; China Medical Treatment Expert Group for Covid-19. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708-20.
7. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054-62. Erratum in: Lancet. 2020; 395(10229):1038.
8. Liu Y, Yan LM, Wan L, Xiang TX, Le A, Liu JM, et al. Viral dynamics in mild and severe cases of COVID-19. Lancet Infect Dis. 2020;20(6):656-7.
9. Lan L, Xu D, Ye G, Xia C, Wang S, Li Y, et al. Positive RT-PCR test results in patients recovered from COVID-19. JAMA. 2020;323(15):1502-3.
10. Wu J, Liu X, Liu J, Liao H, Long S, Zhou N, et al. Coronavirus disease 2019 test results after clinical recovery and hospital discharge among patients in China. JAMA Netw Open. 2020;3(5):e209759.
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).2 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).2 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!ABSTRACT During the COVID-19 pandemic, a case of a long-term persistence of SARS-CoV-2 infection (from March 26 to May 20, 2020) was identified at a private hospital in São Paulo, SP, Brazil. The long-term positivity for SARS-CoV-2 in reverse transcriptase polymerase chain reaction tests of a patient diagnosed with COVID-19 suggests, at least part of patients who recovered, may still carry and transmit the SARS-CoV-2 virus. This fact emphasizes the importance of having at least two negative reverse transcriptase polymerase chain reaction test results for SARS-CoV-2. Serological assays were not particularly helpful in the case described, since the patient had very low antibodies titers at the end of the follow-up period. Low viral loads may not be detected by current molecular methods, leading to wrong conclusions regarding viral clearance.