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Publication . Article . 2020

Effect of TiO2 Nanotube Pore Diameter on Human Mesenchymal Stem Cells and Human Osteoblasts

Juan Shong Khaw; Christopher R. Bowen; Sarah H. Cartmell;
Open Access
Published: 25 Oct 2020 Journal: Nanomaterials, volume 10, page 2,117 (eissn: 2079-4991, Copyright policy )
Publisher: MDPI AG
Country: United Kingdom
The pore diameter of uniformly structured nanotubes can significantly change the behaviour of cells. Recent studies demonstrated that the activation of integrins is affected not by only the surface chemistry between the cell-material interfaces, but also by the features of surface nanotopography, including nanotube diameter. While research has been carried out in this area, there has yet to be a single systemic study to date that succinctly compares the response of both human stem cells and osteoblasts to a range of TiO2 nanotube pore diameters using controlled experiments in a single laboratory. In this paper, we investigate the influence of surface nanotopography on cellular behaviour and osseointegrative properties through a systemic study involving human mesenchymal stem cells (hMSCs) and human osteoblasts (HOBs) on TiO2 nanotubes of 20 nm, 50 nm and 100 nm pore diameters using in-vitro assessments. This detailed study demonstrates the interrelationship between cellular behaviour and nanotopography, revealing that a 20 nm nanotube pore diameter is preferred by hMSCs for the induction of osteogenic differentiation, while 50 nm nanotubular structures are favourable by HOBs for osteoblastic maturation.
Subjects by Vocabulary

Microsoft Academic Graph classification: Stem cell Materials science Nanotube Pore diameter Tio2 nanotube Biophysics Nanotopography Mesenchymal stem cell Integrin biology.protein biology

Library of Congress Subject Headings: lcsh:Chemistry lcsh:QD1-999


General Materials Science, General Chemical Engineering, nanotube, pore diameter, surface nanotopography, stem cell osteogenesis, osteogenic differentiation, osteoblastic maturation, Article

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