<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>
doi: 10.1038/nature13049
pmid: 24476823
Members of a newly described candidate bacterial genus, Entotheonella, have been identified as the sources of the rich array of natural products found in the marine sponge Theonella swinhoei. Two scientists discuss this discovery from the perspectives of microbial ecology and drug discovery. See Article p.58 Almost all drugs and drug candidates from bacteria are produced by a few groups of metabolically rich organisms. That leaves the unculturable — or uncultivated — microbial majority as a largely untapped resource. Here Jorn Piel and colleagues report the use of single-cell and metagenomic analysis to identify two potential 'environmental factories', both members of the candidate genus Entotheonella and symbionts of the chemically rich marine sponge Theonella swinhoei. Importantly they find that the genomes of both microbes encode multiple distinct biosynthetic gene clusters that together account for most of the bioactive polyketides and peptides previously thought to be produced by the sponge host. This discovery identifies Entotheonella and members of the newly proposed phylum Tectomicrobia as a 'biochemically talented' phylum on a par with the actinomycetes.
Deltaproteobacteria, Drug Discovery, Animals
Deltaproteobacteria, Drug Discovery, Animals
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::fde397091cd31ed6e0576ac56c95ad6e&type=result"></script>');
-->
</script>
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::fde397091cd31ed6e0576ac56c95ad6e&type=result"></script>');
-->
</script>
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::fff80aba0e4eda505bac78a2f1b4ce0a&type=result"></script>');
-->
</script>
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::fff80aba0e4eda505bac78a2f1b4ce0a&type=result"></script>');
-->
</script>
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::ffa24ea0a03bf0c2d461485e8e8f8b77&type=result"></script>');
-->
</script>
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::ffa24ea0a03bf0c2d461485e8e8f8b77&type=result"></script>');
-->
</script>
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::fdad6dbba7b908d7c793727659bae426&type=result"></script>');
-->
</script>
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::fdad6dbba7b908d7c793727659bae426&type=result"></script>');
-->
</script>
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::ffbae65f4fcb24477257f0501c950c49&type=result"></script>');
-->
</script>
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::ffbae65f4fcb24477257f0501c950c49&type=result"></script>');
-->
</script>
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::fe5d536fb4d1a9785ad350e51db227b8&type=result"></script>');
-->
</script>
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::fe5d536fb4d1a9785ad350e51db227b8&type=result"></script>');
-->
</script>
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::fdfccc36abde349562a4b8d3e05be639&type=result"></script>');
-->
</script>
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::fdfccc36abde349562a4b8d3e05be639&type=result"></script>');
-->
</script>
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::fe156e5a21e45bf56d4e08353c7ee4ed&type=result"></script>');
-->
</script>
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::fe156e5a21e45bf56d4e08353c7ee4ed&type=result"></script>');
-->
</script>
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::fef87409d8ccd951f523f9e72166ff2e&type=result"></script>');
-->
</script>
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::fef87409d8ccd951f523f9e72166ff2e&type=result"></script>');
-->
</script>
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::fe6e4acf054ffb0cf0fe1250ec60d049&type=result"></script>');
-->
</script>
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=uniprot_____::fe6e4acf054ffb0cf0fe1250ec60d049&type=result"></script>');
-->
</script>
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 463 | |
popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Top 0.1% | |
influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 1% | |
impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 0.1% |