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A fusion learning method to subgroup analysis of Alzheimer's disease
Copyright policy )A fusion learning method to subgroup analysis of Alzheimer's disease
Uncovering the heterogeneity in the disease progression of Alzheimer's is a key factor to disease understanding and treatment development, so that interventions can be tailored to target the subgroups that will benefit most from the treatment, which is an important goal of precision medicine. However, in practice, one top methodological challenge hindering the heterogeneity investigation is that the true subgroup membership of each individual is often unknown. In this article, we aim to identify latent subgroups of individuals who share a common disorder progress over time, to predict latent subgroup memberships, and to estimate and infer the heterogeneous trajectories among the subgroups. To achieve these goals, we apply a concave fusion learning method proposed in Ma and Huang (2017) and Ma et al. (2019) to conduct subgroup analysis for longitudinal trajectories of the Alzheimer's disease data. The heterogeneous trajectories are represented by subject-specific unknown functions which are approximated by B-splines. The concave fusion method can simultaneously estimate the spline coefficients and merge them together for the subjects belonging to the same subgroup to automatically identify subgroups and recover the heterogeneous trajectories. The resulting estimator of the disease trajectory of each subgroup is supported by an asymptotic distribution. It provides a sound theoretical basis for further conducting statistical inference in subgroup analysis..
- Hebei University China (People's Republic of)
- Henan Normal University China (People's Republic of)
- Hainan Normal University China (People's Republic of)
- Henan Normal University China (People's Republic of)
- Huainan Normal University China (People's Republic of)
Methodology (stat.ME), FOS: Computer and information sciences, Statistics and Probability, Articles, Statistics, Probability and Uncertainty, Statistics - Methodology
Methodology (stat.ME), FOS: Computer and information sciences, Statistics and Probability, Articles, Statistics, Probability and Uncertainty, Statistics - Methodology
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citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).1 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).1 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!- Canadian Institutes of Health Research (CIHR)
- National Institutes of Health (NIH)
- 1U01AG024904-01
- NATIONAL INSTITUTE ON AGING
- Hebei University China (People's Republic of)
- Henan Normal University China (People's Republic of)
- Hainan Normal University China (People's Republic of)
- Henan Normal University China (People's Republic of)
- Huainan Normal University China (People's Republic of)
- Hunan Normal University China (People's Republic of)
- Huainan Normal University China (People's Republic of)
- ELI LILLY AND COMPANY United States
- University of California, Riverside United States
- Yunnan Normal University China (People's Republic of)
Uncovering the heterogeneity in the disease progression of Alzheimer's is a key factor to disease understanding and treatment development, so that interventions can be tailored to target the subgroups that will benefit most from the treatment, which is an important goal of precision medicine. However, in practice, one top methodological challenge hindering the heterogeneity investigation is that the true subgroup membership of each individual is often unknown. In this article, we aim to identify latent subgroups of individuals who share a common disorder progress over time, to predict latent subgroup memberships, and to estimate and infer the heterogeneous trajectories among the subgroups. To achieve these goals, we apply a concave fusion learning method proposed in Ma and Huang (2017) and Ma et al. (2019) to conduct subgroup analysis for longitudinal trajectories of the Alzheimer's disease data. The heterogeneous trajectories are represented by subject-specific unknown functions which are approximated by B-splines. The concave fusion method can simultaneously estimate the spline coefficients and merge them together for the subjects belonging to the same subgroup to automatically identify subgroups and recover the heterogeneous trajectories. The resulting estimator of the disease trajectory of each subgroup is supported by an asymptotic distribution. It provides a sound theoretical basis for further conducting statistical inference in subgroup analysis..