You have already added 0 works in your ORCID record related to the merged Research product.
You have already added 0 works in your ORCID record related to the merged Research product.
On the Acoustic Properties of Vaporized Submicron Perfluorocarbon Droplets
Copyright policy )On the Acoustic Properties of Vaporized Submicron Perfluorocarbon Droplets
The acoustic characteristics of microbubbles created from vaporized submicron perfluorocarbon droplets with fluorosurfactant coating are examined. Utilizing ultra-high-speed optical imaging, the acoustic response of individual microbubbles to low-intensity diagnostic ultrasound was observed on clinically relevant time scales of hundreds of milliseconds after vaporization. It was found that the vaporized droplets oscillate non-linearly and exhibit a resonant bubble size shift and increased damping relative to uncoated gas bubbles due to the presence of coating material. Unlike the commercially available lipid-coated ultrasound contrast agents, which may exhibit compression-only behavior, vaporized droplets may exhibit expansion-dominated oscillations. It was further observed that the non-linearity of the acoustic response of the bubbles was comparable to that of SonoVue microbubbles. These results suggest that vaporized submicron perfluorocarbon droplets possess the acoustic characteristics necessary for their potential use as ultrasound contrast agents in clinical practice. (C) 2014 World Federation for Ultrasound in Medicine & Biology.
- University of Toronto Canada
- Erasmus University Rotterdam Netherlands
- University of Twente Netherlands
Medical Subject Headings: technology, industry, and agriculture complex mixtures
Microsoft Academic Graph classification: Fluorosurfactant chemistry.chemical_compound chemistry Diagnostic ultrasound Bubble Vaporization Optoelectronics business.industry business Optics Ultrasound Materials science Microbubbles Coating engineering.material engineering Clinical Practice
IR-90669, METIS-302482, Acoustics, Contrast Media, Equipment Design, Fluorocarbons, Image Processing, Computer-Assisted, Microbubbles, Volatilization, Acoustics and Ultrasonics, Radiology, Nuclear Medicine and imaging, Biophysics, Radiological and Ultrasound Technology
IR-90669, METIS-302482, Acoustics, Contrast Media, Equipment Design, Fluorocarbons, Image Processing, Computer-Assisted, Microbubbles, Volatilization, Acoustics and Ultrasonics, Radiology, Nuclear Medicine and imaging, Biophysics, Radiological and Ultrasound Technology
Medical Subject Headings: technology, industry, and agriculture complex mixtures
Microsoft Academic Graph classification: Fluorosurfactant chemistry.chemical_compound chemistry Diagnostic ultrasound Bubble Vaporization Optoelectronics business.industry business Optics Ultrasound Materials science Microbubbles Coating engineering.material engineering Clinical Practice
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).33 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).33 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!
- Canadian Institutes of Health Research (CIHR)
- University of Toronto Canada
- Erasmus University Rotterdam Netherlands
- University of Twente Netherlands
The acoustic characteristics of microbubbles created from vaporized submicron perfluorocarbon droplets with fluorosurfactant coating are examined. Utilizing ultra-high-speed optical imaging, the acoustic response of individual microbubbles to low-intensity diagnostic ultrasound was observed on clinically relevant time scales of hundreds of milliseconds after vaporization. It was found that the vaporized droplets oscillate non-linearly and exhibit a resonant bubble size shift and increased damping relative to uncoated gas bubbles due to the presence of coating material. Unlike the commercially available lipid-coated ultrasound contrast agents, which may exhibit compression-only behavior, vaporized droplets may exhibit expansion-dominated oscillations. It was further observed that the non-linearity of the acoustic response of the bubbles was comparable to that of SonoVue microbubbles. These results suggest that vaporized submicron perfluorocarbon droplets possess the acoustic characteristics necessary for their potential use as ultrasound contrast agents in clinical practice. (C) 2014 World Federation for Ultrasound in Medicine & Biology.