• shareshare
  • link
  • cite
  • add
auto_awesome_motion View all 4 versions
Publication . Article . 2018

Model for Developing a Health-Related Quality of Life Questionnaire for Chronic Obstructive Pulmonary Disease

Emilija, Nikolić; Aleksandar, Nikolić; Ruža, Stević; Tijana, Brandmajer; Veselin, Mićanović; Jelena, Mašnić;
Open Access   English  
Published: 01 May 2018 Journal: Canadian Respiratory Journal, volume 2,018 (issn: 1198-2241, eissn: 1916-7245, Copyright policy )
Publisher: Hindawi Limited
Introduction. The St. George’s Respiratory Questionnaire (SGRQ), Modified Medical Research Council (mMRC) Dyspnea Scale, Hospital Anxiety and Depression Scale (HADS), and general health questionnaire (SF-36) are widely used for chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD). Aim. We examined the reliability and validity of a modified questionnaire (MQ) to create a model for assessing the health-related quality of life (HRQOL) in COPD. Method. In total, 132 COPD patients completed the MQ. Lung function, smoking index, and exacerbation frequency were measured. Cronbach’s α coefficient of correlation, standard deviation, and multifactorial nonlinear regression analysis were used to verify the internal validity of the MQ and to develop the mathematical model. Results. Female (63) patients had lesser airway obstruction than, and exacerbation frequency similar to that of, male patients. Exacerbation frequency significantly correlated with spirometry parameters in female patients. The MQ total score achieved high internal consistency (Cronbach’s α = 0.89) and showed significant correlations with exacerbation frequency, smoking habit, and spirometry parameters in male patients (p<0.005). Conclusion. The HRQOL questionnaire was shown to be a good indicator of the health status of COPD patients. The mathematical model easily and precisely confirmed the score of HRQOL questionnaire.
Subjects by Vocabulary

Microsoft Academic Graph classification: Cronbach's alpha Quality of life Exacerbation Airway obstruction medicine.disease medicine Hospital Anxiety and Depression Scale Physical therapy medicine.medical_specialty business.industry business Spirometry medicine.diagnostic_test COPD General Health Questionnaire


Diseases of the respiratory system, RC705-779, Article Subject, Research Article, Pulmonary and Respiratory Medicine

33 references, page 1 of 4

Buist, A., McBurnie, M., Vollmer, W.. International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. 2007; 370 (9589): 741-750 [OpenAIRE] [] [DOI]


Jørgen, V., Suzanne, S. H., Alvar, G. A.. Global strategy for diagnosis, management, and prevention of COPD: GOLD executive summary. 2013; 187 (4): 347-365


Miravitlles, M., Molina, J., Quintano, J. A., Campuzano, A., Perez, J., Roncero, C.. Factors associated with depression and severe depression in patients with COPD. 2014; 108 (11): 1615-1625 [OpenAIRE] [] [DOI]

Zhang, M. W., Ho, R. C., Cheung, M. W., Fu, E., Mak, A.. Prevalence of depressive symptoms in patients with chronic obstructive pulmonary disease: a systematic review, meta-analysis and meta-regression. 2011; 33 (3): 217-223 [OpenAIRE] [] [DOI]

Niti, M., Ng, T.-P., Kua, E. H., Ho, R. C. M., Tan, C. H.. Depression and chronic medical illnesses in Asian older adults: the role of subjective health and functional status. 2007; 22 (11): 1087-1094 [OpenAIRE] [] [DOI]

Liu, Y., Ho, R. C., Mak, A.. Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression. 2012; 139 (3): 230-239 [OpenAIRE] [] [DOI]

Emami Ardestani, M., Omid, Z.. Role of serum interleukin 6, albumin and C-reactive protein in COPD patients. 2015; 14 (2): 134-140 [OpenAIRE]

Lu, Y., Ho, R., Lim, T. K.. Neuropeptide Y may mediate psychological stress and enhance TH2 inflammatory response in asthma. 2015; 135 (4): 1061-1063 [OpenAIRE] [] [DOI]