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Biomaterials Science
Article . 2023
License: CC BY NC
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Engineering optical tools for remotely controlled brain stimulation and regeneration

Authors: Artur Filipe Rodrigues; Catarina Rebelo; Tiago Reis; Susana Simões; Liliana Bernardino; João Peça; Lino Ferreira;

Engineering optical tools for remotely controlled brain stimulation and regeneration

Abstract

Neurological disorders are one of the world's leading medical and societal challenges due to the lack of efficacy of the first line treatment. Although pharmacological and non-pharmacological interventions have been employed with the aim of regulating neuronal activity and survival, they have failed to avoid symptom relapse and disease progression in the vast majority of patients. In the last 5 years, advanced drug delivery systems delivering bioactive molecules and neuromodulation strategies have been developed to promote tissue regeneration and remodel neuronal circuitry. However, both approaches still have limited spatial and temporal precision over the desired target regions. While external stimuli such as electromagnetic fields and ultrasound have been employed in the clinic for non-invasive neuromodulation, they do not have the capability of offering single-cell spatial resolution as light stimulation. Herein, we review the latest progress in this area of study and discuss the prospects of using light-responsive nanomaterials to achieve on-demand delivery of drugs and neuromodulation, with the aim of achieving brain stimulation and regeneration.

Keywords

Neurons, Drug Delivery Systems, Biomedical Engineering, Humans, Brain, General Materials Science, Ultrasonography

149 references, page 1 of 15

2 D. C. Park and P. Reuter-Lorenz, Annu. Rev. Psychol., 2009, 60, 173-196.

3 M. Manford, J. Neurol., 2017, 264, 1811-1824.

4 G. J. Hankey, Lancet, 2017, 389, 641-654.

5 S. Pinho, M. H. Macedo, C. Rebelo, B. Sarmento and L. Ferreira, Drug Discovery Today, 2018, 23, 1071-1078.

6 C. R. Freed, P. E. Greene, R. E. Breeze, W.-Y. Tsai, W. DuMouchel, R. Kao, S. Dillon, H. Winfield, S. Culver, J. Q. Trojanowski, D. Eidelberg and S. Fahn, N. Engl. J. Med., 2001, 344, 710-719.

7 D. Kondziolka, G. K. Steinberg, L. Wechsler, C. C. Meltzer, E. Elder, J. Gebel, S. DeCesare, T. Jovin, R. Zafonte, J. Lebowitz, J. C. Flickinger, D. Tong, M. P. Marks, C. Jamieson, D. Luu, T. Bell-Stephens and J. Teraoka, J. Neurosurg., 2005, 103, 38-45.

8 R. Mays and R. Deans, Transfusion, 2016, 56, 6S-8S.

9 L.-Y. Qiao, F.-J. Huang, M. Zhao, J.-H. Xie, J. Shi, J. Wang, X.-Z. Lin, H. Zuo, Y.-L. Wang and T.-C. Geng, Cell Transplant., 2014, 23, S65-S72.

10 K. W. Muir, D. Bulters, M. Willmot, N. Sprigg, A. Dixit, N. Ward, P. Tyrrell, A. Majid, L. Dunn, P. Bath, J. Howell, P. Stroemer, K. Pollock and J. Sinden, J. Neurol., Neurosurg. Psychiatry, 2020, 91, 396-401.

11 W. Tai, X. M. Xu and C. L. Zhang, Front. Cell. Neurosci., 2020, 14, 107.

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  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Funded by
EC| RESETageing
Project
RESETageing
RESEarch for healThy AGEING
  • Funder: European Commission (EC)
  • Project Code: 952266
  • Funding stream: H2020 | CSA
,
EC| LIGHTEST
Project
LIGHTEST
LIght-responsive GrapHene-based inTerfaces for Electrical STimulation
  • Funder: European Commission (EC)
  • Project Code: 101003413
  • Funding stream: H2020 | MSCA-IF-EF-ST
Validated by funder | sysimport:crosswalk:repository
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