Synthesis of 5-thiocarbomoyl- and 5-(thiazol-2-yl)-2,3,4,4a,5,6-hexahydro-1Н-pyrido[1,2-a]quinoline-5-carbonitriles
Copyright policy )Synthesis of 5-thiocarbomoyl- and 5-(thiazol-2-yl)-2,3,4,4a,5,6-hexahydro-1Н-pyrido[1,2-a]quinoline-5-carbonitriles
The tert-amino effect cyclizations are an efficient and convenient route to synthetically as well as biologically important ring-fused tetrahydroquinolines. The method is operationally simple and highly diastereoselective. Herein we representour studies of the tert-amino effect reaction ortho-dialkylaminobenzaldehydes and cyanthioacetamide or [4-aryl-1,3-thiazol-2yl]acetonitrile.It was found 9-chloro-5-(4-phenylthiazol-2-yl)-2,3,4,4a,5,6-hexahydro-1Н-pyrido[1,2-a]quinoline-5-carbinitrile can easily be obtained from 9-chloro-5-cyano-2,3,4,4а,5,6-hexahydro-1H-pyrido[1,2-a] quinoline-5-carbothioamide andα-bromoacetophenone condensation.
циклизация, TERT-AMINO EFFECT, трет-амино эффект; азотсодержащие гетероциклы; циклизация; тиоамиды, QUINOLINE, АЗОТСОДЕРЖАЩИЕ ГЕТЕРОЦИКЛЫ, CYCLIZATION, тиоамиды, азотсодержащие гетероциклы, THIOAMIDE, ТРЕТ-АМИНО ЭФФЕКТ, Chemistry, ТИОАМИДЫ, трет-амино эффект, QD1-999, tert-amino effect; quinoline; cyclization; thioamide, ЦИКЛИЗАЦИЯ
циклизация, TERT-AMINO EFFECT, трет-амино эффект; азотсодержащие гетероциклы; циклизация; тиоамиды, QUINOLINE, АЗОТСОДЕРЖАЩИЕ ГЕТЕРОЦИКЛЫ, CYCLIZATION, тиоамиды, азотсодержащие гетероциклы, THIOAMIDE, ТРЕТ-АМИНО ЭФФЕКТ, Chemistry, ТИОАМИДЫ, трет-амино эффект, QD1-999, tert-amino effect; quinoline; cyclization; thioamide, ЦИКЛИЗАЦИЯ
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