Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program
Copyright policy )Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program
Significance The mitochondria, organelles that produce the largest amounts of ATP and reactive oxygen species (mROS) in living cells, are equipped with a universal mechanism that can completely prevent mROS production. This mechanism consists of mild depolarization of the inner mitochondrial membrane to decrease the membrane potential to a level sufficient to form ATP but insufficient to generate mROS. In short-lived mice, aging is accompanied by inactivation of the mild depolarization mechanism, resulting in chronic poisoning of the organism with mROS. However, mild depolarization still functions for many years in long-lived naked mole rats and bats.
- Leibniz Association Germany
- Lomonosov Moscow State University Russian Federation
- University of Melbourne Australia
- Leibniz Institute for Zoo and Wildlife Research Germany
- Department of Ecology and Evolution Switzerland
570, Aging, mitochondria ; mild depolarization ; antioxidant ; aging ; naked mole rat, 610, Electron Transport, Mitochondrial Proteins, Mice, Species Specificity, Chiroptera, Hexokinase, Animals, Membrane Potential, Mitochondrial, Mole Rats, Adenosine Diphosphate/metabolism; Aging; Animals; Chiroptera; Creatine/metabolism; Electron Transport; Embryo, Mammalian; Glucose/metabolism; Hexokinase/metabolism; Membrane Potential, Mitochondrial; Mice; Mitochondria/metabolism; Mitochondria/physiology; Mitochondrial Membranes/enzymology; Mitochondrial Membranes/metabolism; Mitochondrial Membranes/physiology; Mitochondrial Proteins/metabolism; Mole Rats; Organ Specificity; Reactive Oxygen Species/metabolism; Species Specificity; aging; antioxidant; mild depolarization; mitochondria; naked mole rat, Biological Sciences, Creatine, Embryo, Mammalian, Mitochondria, Adenosine Diphosphate, Glucose, Organ Specificity, Mitochondrial Membranes, Reactive Oxygen Species
570, Aging, mitochondria ; mild depolarization ; antioxidant ; aging ; naked mole rat, 610, Electron Transport, Mitochondrial Proteins, Mice, Species Specificity, Chiroptera, Hexokinase, Animals, Membrane Potential, Mitochondrial, Mole Rats, Adenosine Diphosphate/metabolism; Aging; Animals; Chiroptera; Creatine/metabolism; Electron Transport; Embryo, Mammalian; Glucose/metabolism; Hexokinase/metabolism; Membrane Potential, Mitochondrial; Mice; Mitochondria/metabolism; Mitochondria/physiology; Mitochondrial Membranes/enzymology; Mitochondrial Membranes/metabolism; Mitochondrial Membranes/physiology; Mitochondrial Proteins/metabolism; Mole Rats; Organ Specificity; Reactive Oxygen Species/metabolism; Species Specificity; aging; antioxidant; mild depolarization; mitochondria; naked mole rat, Biological Sciences, Creatine, Embryo, Mammalian, Mitochondria, Adenosine Diphosphate, Glucose, Organ Specificity, Mitochondrial Membranes, Reactive Oxygen Species
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).141 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1%
Citations provided by BIP!Popularity provided by BIP!