Downloads provided by UsageCountsAntidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014: Incidence and comorbidities of antidepressant initiators
Copyright policy ) Joan Forns; Anton Pottegård; Tammo Reinders; Beatriz Poblador-Plou; Rosa Morros; Lena Brandt; Miguel Cainzos-Achirica; +12 Authors
Joan Forns; Anton Pottegård; Tammo Reinders; Beatriz Poblador-Plou; Rosa Morros; Lena Brandt; Miguel Cainzos-Achirica; Maja Hellfritzsch; Tania Schink; Alexandra Prados-Torres; Maria Giner-Soriano; David Hägg; Jesper Hallas; Jordi Cortés; Emmanuelle Jacquot; Nicolas Deltour; Susana Perez-Gutthann; Manel Pladevall; Johan Reutfors;
Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014: Incidence and comorbidities of antidepressant initiators
We aimed to describe patterns of use and characteristics of 10 commonly used antidepressants for the period 2009-2014 in Denmark, Germany, Spain, and Sweden.Adult initiators from 2009 to 2014 of each study antidepressant were identified in four countries using five data sources: the Danish National registers, GePaRD (Germany), EpiChron (Aragon, Spain), SIDIAP (Catalonia, Spain), and the Swedish National Registers. The study included 10 study antidepressants: citalopram, escitalopram, fluoxetine, paroxetine, sertraline, duloxetine, venlafaxine, amitriptyline, mirtazapine, and agomelatine.Citalopram was the most prescribed study antidepressant, followed by mirtazapine. Paroxetine and agomelatine were the least prescribed antidepressants. Mirtazapine was widely used among older antidepressant initiators with higher percentages of comorbidities at baseline, and fluoxetine was used among young patients. Citalopram and amitriptyline had the lowest percentage of multiple antidepressant use in the 12 months prior to the current treatment episode, while agomelatine, duloxetine, and venlafaxine had the highest percentage of multiple antidepressant use in the year prior to the current treatment episode.The most important limitations are exposure information based on filled prescriptions, focus on antidepressant initiators only, lack of information on the indication, and heterogeneity of the type of data across data sources.Results of this study including 4.8 million study antidepressant initiators of study antidepressants suggest that citalopram and mirtazapine are the most commonly prescribed antidepressants. Agomelatine and paroxetine were the least used antidepressants in the participating populations. Mirtazapine was the antidepressant most commonly prescribed among older antidepressant initiators with high percentage of comorbidities at baseline, whereas fluoxetine was commonly used among young patients.
Male, Biologia, Drug utilization study ; Comorbidity ; Antidepressants ; Europe, :Environment and Public Health::Public Health::Epidemiologic Factors::Comorbidity [HEALTH CARE], :Matemàtiques i estadística::Matemàtica aplicada a les ciències [Àrees temàtiques de la UPC], Comorbidity, cellular and medical topics, ATENCIÓN DE SALUD::ambiente y salud pública::salud pública::factores epidemiológicos::comorbilidad, sample surveys, Drug utilization study, :Health Services Administration::Organization and Administration::Pharmacy Administration::Drug Utilization [HEALTH CARE], Registries, Practice Patterns, Physicians', :ambiente y salud pública::salud pública::factores epidemiológicos::comorbilidad [ATENCIÓN DE SALUD], :Administración de los Servicios de Salud::Organización y Administración::Administración Farmacéutica::Utilización de Medicamentos [ATENCIÓN DE SALUD], Age Factors, Classificació AMS::92 Biology and other natural sciences::92C Physiological, cellular and medical topics, Antidepressants, Middle Aged, Antidepressive Agents, Europe, Female, HEALTH CARE::Health Services Administration::Organization and Administration::Pharmacy Administration::Drug Utilization, Adult, Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística matemàtica::Anàlisi multivariant, Classificació AMS::62 Statistics::62D05 Sampling theory, sample surveys, Medicaments - Ús, :62 Statistics::62D05 Sampling theory, sample surveys [Classificació AMS], Sex Factors, Comorbiditat, Classificació AMS::62 Statistics::62D05 Sampling theory, :Matemàtiques i estadística::Estadística matemàtica::Anàlisi multivariant [Àrees temàtiques de la UPC], Humans, HEALTH CARE::Environment and Public Health::Public Health::Epidemiologic Factors::Comorbidity, Sampling (Statistics), Biology, :92 Biology and other natural sciences::92C Physiological, cellular and medical topics [Classificació AMS], Aged, Depressive Disorder, Pharmacoepidemiology, farmacoepidemiología, Classificació AMS::92 Biology and other natural sciences::92C Physiological, Drug Utilization, ATENCIÓN DE SALUD::administración de los servicios de salud::organización y administración::administración farmacéutica::utilización de medicamentos, Àrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències, Mostreig (Estadística), Farmacoepidemiologia
Male, Biologia, Drug utilization study ; Comorbidity ; Antidepressants ; Europe, :Environment and Public Health::Public Health::Epidemiologic Factors::Comorbidity [HEALTH CARE], :Matemàtiques i estadística::Matemàtica aplicada a les ciències [Àrees temàtiques de la UPC], Comorbidity, cellular and medical topics, ATENCIÓN DE SALUD::ambiente y salud pública::salud pública::factores epidemiológicos::comorbilidad, sample surveys, Drug utilization study, :Health Services Administration::Organization and Administration::Pharmacy Administration::Drug Utilization [HEALTH CARE], Registries, Practice Patterns, Physicians', :ambiente y salud pública::salud pública::factores epidemiológicos::comorbilidad [ATENCIÓN DE SALUD], :Administración de los Servicios de Salud::Organización y Administración::Administración Farmacéutica::Utilización de Medicamentos [ATENCIÓN DE SALUD], Age Factors, Classificació AMS::92 Biology and other natural sciences::92C Physiological, cellular and medical topics, Antidepressants, Middle Aged, Antidepressive Agents, Europe, Female, HEALTH CARE::Health Services Administration::Organization and Administration::Pharmacy Administration::Drug Utilization, Adult, Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística matemàtica::Anàlisi multivariant, Classificació AMS::62 Statistics::62D05 Sampling theory, sample surveys, Medicaments - Ús, :62 Statistics::62D05 Sampling theory, sample surveys [Classificació AMS], Sex Factors, Comorbiditat, Classificació AMS::62 Statistics::62D05 Sampling theory, :Matemàtiques i estadística::Estadística matemàtica::Anàlisi multivariant [Àrees temàtiques de la UPC], Humans, HEALTH CARE::Environment and Public Health::Public Health::Epidemiologic Factors::Comorbidity, Sampling (Statistics), Biology, :92 Biology and other natural sciences::92C Physiological, cellular and medical topics [Classificació AMS], Aged, Depressive Disorder, Pharmacoepidemiology, farmacoepidemiología, Classificació AMS::92 Biology and other natural sciences::92C Physiological, Drug Utilization, ATENCIÓN DE SALUD::administración de los servicios de salud::organización y administración::administración farmacéutica::utilización de medicamentos, Àrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències, Mostreig (Estadística), Farmacoepidemiologia
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