The numerical results of mathematical modeling of a two-phase axisymmetric swirling turbulent flow in a separation zone of a centrifugal separator are presented. The motion of the carrier gas flow is described by the Reynolds-averaged Navier-Stokes equations. A system of equations is enclosed by the Spalart-Allmaras turbulence model. The study is based on the obtained fields of averaged velocities of the carrier medium, with account for turbulent diffusion. Numerical solution to the problem is implemented using the semi-implicit method for pressure linked equations (SIMPLE). The results obtained when the solid phase effect on the air flow dynamics is taken into account are compared with those obtained when the effect is left out of account. The numerical calculations are validated using the experimental data.