PET/CT has become an indispensable technique in the management of patients with most hematological malignancies. This method provides effective staging of the disease, reflects the state of tumor tissue both during and after treatment, and gives the basis to rule-out or -in a tumor relapse. At the present stage of its development, however, PET/CT being a promising diagnostic technique implies a greater potential for clinical professionals. PET/CT can replace other imaging techniques, it can be used for prognostic stratification of patients as well as for treatment-related and other kinds of decision-making navigation. These tendencies take shape and develop very quickly, which makes it impossible to cover all of them in a single review. The aim of the present paper is to dwell on the key opportunities and promising areas of PET/CT development with regard to its potential clinical significance.