Theoretical and practical issues of implementation of interdisciplinary approach in the system of foreign language training of University students of non-linguistic specialties are examined. The research urgency is caused by necessity of formation of holistic scientific worldview of future professionals on the basis of interdisciplinary integration in the crisis of disciplinary knowledge. Genesis of the interdisciplinary approach to general and higher education is covered. A review of the domestic and foreign psychological-pedagogical and didactic literature covering the experience of application of interdisciplinary approach in University practice is made. Concepts of “meta-competences,” “meta-subject competences,” “over-professional competences,” “soft skills,” etc. are distinguished. The structure of foreign models of the formation of meta-competency of graduates that meet the requirements of employers are described. Organizational-pedagogical conditions of realization of interdisciplinary approach in the system of non-linguistic higher education are analyzed. There is a sample list of meta-competences, which can be effectively formed in the process of foreign language training in higher education. Techniques and technologies of forming meta-competences of specialists of non-linguistic profile by means of the discipline “Foreign language” are classified. The results of experimental work on forming meta-competences in students of the undergraduate training of 06.03.01 Biology field of study are described. The prospects of application of interdisciplinary approach in the field of vocational didactics are examined.