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Ukrainian Journal of Pediatric Endocrinology
Article . 2020 . Peer-reviewed
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Criteria of hypoandrogenism in adolescent boys

Authors: Turchina, S. I.; Коstenko, Т. P. ; Kosovtsova, G. V.; Varodova, О. V. ;

Criteria of hypoandrogenism in adolescent boys

Abstract

Objective — to develop criteria for assessing androgenic status in adolescent boys aged 13 — 17.Materials and methods. We examined 176 practically healthy boys aged 13 — 17 with harmonious physical development, physiological course of puberty and normal sexual development (SD). We evaluated the sexual and physical development of boys, determined the levels of total testosterone (TT) and estradiol (E2), sex steroid‑binding globulin (SSBG), calculated free androgen index (FAI). Statistical analysis was performed using software packages SPSS Statistics 17.0 and Microsoft Excel 2010. The critical level of significance of 0.05 for testing statistical hypotheses when comparing groups was used.Results. It was found that 13‑year‑old boys with normal SD are characterized by a wide range of fluctuations in normal TT values from 1.97 to 26.30 nmol/L. This indicates the inappropriateness of talking about hypoandrogenism (HA) at this age, especially in the case of a normal level of SD. The mean TT level in 13‑year‑old boys was significantly lower than in older adolescents (11.76 (1.96; 26.30) nmol/L, p 0.05), averaging at 31.21 (18.20; 40.05) nmol/L. There were no significant differences in E2 level in boys of 13 — 17 years old (p > 0.05). It was found that, starting from the age of 15, there is a decrease in the concentration of SSBG and an increase in FAI. Based on the study of the frequency distribution of indicators in boys of 13, 14, 15, 16 and 17 years old, a qualitative assessment of TT indicators was developed. It has been proven that HA in adolescence can be diagnosed starting from the age of 14, in the case of a decrease in the TT level less than 12.0 nmol/L. The range of TT corresponding to various degrees of HA was determined: degree I — 8.0‑ < 12.0 nmol/L; degree II — 4.0‑ < 8.0 nmol/L; degree III – < 4.0 nmol/L.Conclusions. The indicators of sex steroids, SSBG and FAI were studied in healthy 13 — 17 year old boys. The criteria for determining HA and its degrees in boys aged 14 — 17 have been substantiated.

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Keywords

androgenic status, андрогенный статус, гипоандрогения, adolescent boys, хлопчики‑підлітки, hypoandrogenism, андрогенний статус, гіпоандрогенія, мальчики‑подростки

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
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