Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults
Copyright policy )Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults
New-borns raise limited antibody responses to most T cell-dependent antigens but little is known about neonatal T lymphocyte responses to vaccines. In this study, we compared the immune response induced by the hepatitis B vaccine in new-borns and nai;ve adults. Infants produced markedly higher serum anti-hepatitis B surface (HBs) antibody titres than adults. This was not associated with greater HBs Ag-specific Th2 cytokine responses but with lower primary IFN-gamma responses. At 1 year, the infant memory response to HBs Ag was characterised by higher Th2 responses than those of adults. We conclude that neonatal antibody and T cell responses to hepatitis B vaccine differ from those induced in adults.
- University of Geneva Switzerland
- Université Libre de Bruxelles Belgium
- Northamptonshire Healthcare NHS Foundation Trust United Kingdom
- University of London United Kingdom
- MRC Weatherall Institute of Molecular Medicine United Kingdom
Adult, Male, Aging, Adolescent, Hepatitis Antibodies/analysis/biosynthesis, Hepatitis B Vaccines -- administration & dosage, 616.07, Th2 Cells/immunology, 618, Interferon-gamma, Th2 Cells, Adjuvants, Immunologic, Immunologic, Interferon-gamma -- biosynthesis, Humans, Hepatitis B Vaccines, Adjuvants, Hepatitis Antibodies, Th2 Cells -- immunology, Interferon-gamma/biosynthesis/physiology, Aging/immunology, BCG Vaccine/immunology, Immunity, Cellular, BCG Vaccine -- immunology, Interferon-gamma -- physiology, Hepatitis Antibodies -- biosynthesis, Hepatitis B Vaccines -- immunology, Immunity, Infant, Newborn, Infant, Hepatitis Antibodies -- analysis, Sciences bio-médicales et agricoles, Newborn, Cellular -- immunology, Aging -- immunology, Immunologic Memory -- immunology, Immunity, Cellular/immunology, Immunologic Memory/immunology, BCG Vaccine, Female, Immunization, Hepatitis B Vaccines/administration & dosage/immunology, Immunologic Memory, ddc: ddc:616.07, ddc: ddc:618
Adult, Male, Aging, Adolescent, Hepatitis Antibodies/analysis/biosynthesis, Hepatitis B Vaccines -- administration & dosage, 616.07, Th2 Cells/immunology, 618, Interferon-gamma, Th2 Cells, Adjuvants, Immunologic, Immunologic, Interferon-gamma -- biosynthesis, Humans, Hepatitis B Vaccines, Adjuvants, Hepatitis Antibodies, Th2 Cells -- immunology, Interferon-gamma/biosynthesis/physiology, Aging/immunology, BCG Vaccine/immunology, Immunity, Cellular, BCG Vaccine -- immunology, Interferon-gamma -- physiology, Hepatitis Antibodies -- biosynthesis, Hepatitis B Vaccines -- immunology, Immunity, Infant, Newborn, Infant, Hepatitis Antibodies -- analysis, Sciences bio-médicales et agricoles, Newborn, Cellular -- immunology, Aging -- immunology, Immunologic Memory -- immunology, Immunity, Cellular/immunology, Immunologic Memory/immunology, BCG Vaccine, Female, Immunization, Hepatitis B Vaccines/administration & dosage/immunology, Immunologic Memory, ddc: ddc:616.07, ddc: ddc:618
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