Introduction. The article proposes a model for assessing the integrated safety of the labor process of workers with the risk of the spread of infectious respiratory diseases, for the development of which multifactorial dependences of occupational risk on working conditions at the workplace were used, taking into account the likelihood of contracting coronavirus infection. Problem Statement. The objective of this study is to formulate methodological aspects of ensuring the safety of the workplace and the working environment, reflecting the need for constant epidemiological monitoring of objects of control (employees and the ways of virus transmission) with an assessment of the controlled parameters. Theoretical Part. Official data provided by the Federal State Statistics Service was used as basic information. Conclusion. The results of the analysis indicate the need for a rapid assessment of occupational risk, taking into account the epidemiological circumstances