Objective – to establish the effectiveness of Antral in the treatment of exacerbation phase of chronic pancreatitis (CP) based on a comprehensive assessment of the clinical course of CP and oxidative-antioxidant homeostasis.Material and methods. 52 patients with CP of mixed etiology in the moderate severity exacerbation phase were examined. To represent the effectiveness of treatment on a random basis, two representative groups of patients were formed. The average age of patients was (41.3±4.5) years. The design of the research included clinical, laboratory, biochemical blood tests, enzyme immunoassay, biochemical analysis of duodenal contents, coprogram, ultrasonography (USG) of the pancreas. Analysis of clinical, USG manifestations of CP, biochemical, laboratory indicators of the functional state of the pancreas was performed according to conventional methods, which were studied in the dynamics after 30 days of treatment.Results. Before treatment, a significant intensity of oxidative stress with an increase in the content of intermediate and final products of lipid peroxidation (1.6-1.7 times, p<0.05), oxidative protein modification (2.3 times), p<0.05), induction of nitrosative stress (1.5 times, p<0.05), which arose against the background of a significant deficiency of reduced glutathione in the blood (1.3 times, p<0.05) and were accompanied by a compensatory increase of catalase activity (by 1.5 times, p<0,05) detected in patients with CP. The prescription of Antral on the background of complex therapy of exacerbation of CP for 30 days led to a significant correction of oxidative-antioxidant homeostasis in patients with CP with a significant decrease in blood malonic aldehyde (1.3 times, p<0.05), isolated double bonds (1.5 times, p<0.05), the alkaline aldehyde and ketondinitrophenylhydrazones (1.8 times, p<0.05), nitrites/nitrates (1.5 times, p<0.05) due to the significant increase and normalization of the content of reduced glutathione in erythrocytes (1.3 times, p <0.05), normalization of catalase activity, accompanied by probable elimination of clinical manifestations of exacerbation of CP: astheno-vegetative syndrome (OR=3.18, 95% CI) 1.18- 8.63), pain in the left hypochondrium (OR=2.67, 95% CI 1.05-6.75), stomach bloating (OR=3.06, 95% CI 1.13-8, 32) (p<0,05), elimination of inflammatory edema of the pancreas (OR=2,67, 95% CI 1,05-6,75), hyperenzymaemia syndrome, inflammatory syndrome (OR=3,22, 95% CI 1), 22-8,94) and increase of exocrine function of the pancreas (OR=3,77, 95% D and 1.24-11.49) (p<0.05).Conclusions. The proposed complex therapy, with the addition of Antral, demonstrated a higher degree of effectiveness, compared with the basic therapy, in achieving the antioxidant effect, which allowed reducing the intensity of lipid peroxidation and protein oxidative modification, nitrosative stress, which are the main elements in the pathogenesis of exacerbation of chronic pancreatitis.