Analysis of structural brain asymmetries in attention‐deficit/hyperactivity disorder in 39 datasets
Copyright policy )Analysis of structural brain asymmetries in attention‐deficit/hyperactivity disorder in 39 datasets
ObjectiveSome studies have suggested alterations of structural brain asymmetry in attention‐deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left‐right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium.MethodsWe analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries.ResultsThere was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (t = 2.1, p = .04). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (t = 2.7, p = .01) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen’s d from −0.18 to 0.18) and would not survive study‐wide correction for multiple testing.ConclusionPrior studies of altered structural brain asymmetry in ADHD were likely underpowered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait.
- Trinity College Dublin Ireland
- Spanish National Research Council Spain
- University of Melbourne Australia
- Boston Children's Hospital United States
- University of Barcelona Spain
CORTICAL THICKNESS MEASUREMENTS, Dominància cerebral, Large-scale data, Autism Spectrum Disorder, Biological Psychology, 150, Attention-deficit, name=Pediatrics, Clinical sciences, CHILDREN, ADULT ADHD, Clinical and health psychology, Hyperactivity disorder, 130 000 Cognitive Neurology & Memory, GENETIC INFLUENCES, Psychology, 2.1 Biological and endogenous factors, Brain laterality, ANATOMÍA::sistema nervioso::sistema nervioso central::encéfalo, Child, info:eu-repo/classification/ddc/610, Pediatric, large-scale data, ddc:610, brain laterality, scale data, Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen, Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging, Brain, /dk/atira/pure/subjectarea/asjc/2700/2738, Psychiatry - Radboud University Medical Center, PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity, Perinatology, Mental Illness, Magnetic Resonance Imaging, ANATOMY::Nervous System::Central Nervous System::Brain, and Child Health, Mental Health, Attention‐, /dk/atira/pure/subjectarea/asjc/2700/2735, CAUDATE-NUCLEUS, hyperactivity disorder, name=Developmental and Educational Psychology, Mental health, Cognitive Sciences, Neuroinformatics, Adult, RIGHT-HEMISPHERE, Adolescent, Clinical Sciences, 610, deficit, Developmental & Child Psychology, SURFACE-AREA, name=Psychiatry and Mental health, ENIGMA ADHD Working Group, SDG 3 - Good Health and Well-being, Clinical Research, Behavioral and Social Science, Humans, large‐, structural MRI, DEFICIT-HYPERACTIVITY-DISORDER, PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad, Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical Neuroscience, AUTISM SPECTRUM DISORDER, /dk/atira/pure/subjectarea/asjc/3200/3204, Neurosciences, Applied and developmental psychology, Cervell - Imatgeria, Brain/diagnostic imaging, Attention Deficit Hyperactivity Disorder (ADHD), Brain Disorders, Structural MRI, Trastorn per dèficit d'atenció amb hiperactivitat, Attention Deficit Disorder with Hyperactivity, brain asymmetry, PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos generalizados del desarrollo del niño::trastorno del espectro del autismo, Human Genetics - Radboud University Medical Center, Brain asymmetry, Caudate Nucleus, MATTER, PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Child Development Disorders, Pervasive::Autism Spectrum Disorder
CORTICAL THICKNESS MEASUREMENTS, Dominància cerebral, Large-scale data, Autism Spectrum Disorder, Biological Psychology, 150, Attention-deficit, name=Pediatrics, Clinical sciences, CHILDREN, ADULT ADHD, Clinical and health psychology, Hyperactivity disorder, 130 000 Cognitive Neurology & Memory, GENETIC INFLUENCES, Psychology, 2.1 Biological and endogenous factors, Brain laterality, ANATOMÍA::sistema nervioso::sistema nervioso central::encéfalo, Child, info:eu-repo/classification/ddc/610, Pediatric, large-scale data, ddc:610, brain laterality, scale data, Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen, Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging, Brain, /dk/atira/pure/subjectarea/asjc/2700/2738, Psychiatry - Radboud University Medical Center, PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity, Perinatology, Mental Illness, Magnetic Resonance Imaging, ANATOMY::Nervous System::Central Nervous System::Brain, and Child Health, Mental Health, Attention‐, /dk/atira/pure/subjectarea/asjc/2700/2735, CAUDATE-NUCLEUS, hyperactivity disorder, name=Developmental and Educational Psychology, Mental health, Cognitive Sciences, Neuroinformatics, Adult, RIGHT-HEMISPHERE, Adolescent, Clinical Sciences, 610, deficit, Developmental & Child Psychology, SURFACE-AREA, name=Psychiatry and Mental health, ENIGMA ADHD Working Group, SDG 3 - Good Health and Well-being, Clinical Research, Behavioral and Social Science, Humans, large‐, structural MRI, DEFICIT-HYPERACTIVITY-DISORDER, PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad, Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical Neuroscience, AUTISM SPECTRUM DISORDER, /dk/atira/pure/subjectarea/asjc/3200/3204, Neurosciences, Applied and developmental psychology, Cervell - Imatgeria, Brain/diagnostic imaging, Attention Deficit Hyperactivity Disorder (ADHD), Brain Disorders, Structural MRI, Trastorn per dèficit d'atenció amb hiperactivitat, Attention Deficit Disorder with Hyperactivity, brain asymmetry, PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos generalizados del desarrollo del niño::trastorno del espectro del autismo, Human Genetics - Radboud University Medical Center, Brain asymmetry, Caudate Nucleus, MATTER, PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Child Development Disorders, Pervasive::Autism Spectrum Disorder
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