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A noise-robust post-processing pipeline for accelerated phase-cycled 23Na Multi-Quantum Coherences MRI

Authors: Licht, Christian; Ilicak, Efe; Boada, Fernando; Guye, Maxime; Zöllner, Frank; Schad, Lothar; Rapacchi, Stanislas;

A noise-robust post-processing pipeline for accelerated phase-cycled 23Na Multi-Quantum Coherences MRI

Abstract

To develop an improved post-processing pipeline for noise-robust accelerated phase-cycled Cartesian Single (SQ) and Triple Quantum (TQ) sodium (23Na) Magnetic Resonance Imaging (MRI) of in vivo human brain at 7 T.Our pipeline aims to tackle the challenges of 23Na Multi-Quantum Coherences (MQC) MRI including low Signal-to-Noise Ratio (SNR) and time-consuming Radiofrequency (RF) phase-cycling. Our method combines low-rank k-space denoising for SNR enhancement with Dynamic Mode Decomposition (DMD) to robustly separate SQ and TQ signal components. This separation is crucial for computing the TQ/SQ ratio, a key parameter of 23Na MQC MRI. We validated our pipeline in silico, in vitro and in vivo in healthy volunteers, comparing it with conventional denoising and Fourier transform (FT) methods. Additionally, we assessed its robustness through ablation experiments simulating a corrupted RF phase-cycle step.Our denoising algorithm doubled SNR compared to non-denoised images and enhanced SNR by up to 29% compared to Wavelet denoising. The low-rank approach produced high-quality images even at later echo times, allowing reduced signal averaging. DMD effectively separated the SQ and TQ signals, even with missing RF phase cycle steps, resulting in superior Structural Similarity (SSIM) of 0.89±0.024 and lower Root Mean Squared Error (RMSE) of 0.055±0.008 compared to conventional FT methods (SSIM=0.71±0.061, RMSE=0.144±0.036). This pipeline enabled high-quality 8x8x15mm3 in vivo 23Na MQC MRI, with a reduction in acquisition time from 48 to 10 min at 7 T.The proposed pipeline improves robustness in 23Na MQC MRI by exploiting low-rank properties to denoise signals and DMD to effectively separate SQ and TQ signals. This approach ensures high-quality MR images of both SQ and TQ components, even in accelerated and incomplete RF phase-cycling cases.

Keywords

Original Paper, Single and triple quantum imaging, Sodium, Brain, Neuroimaging, Signal-To-Noise Ratio, Magnetic Resonance Imaging, Sodium multi-quantum coherences, Low-rank, Dynamic mode decomposition, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, Sodium MRI, Image Processing, Computer-Assisted, Humans, Humans; Magnetic Resonance Imaging/methods; Signal-To-Noise Ratio; Brain/diagnostic imaging; Algorithms; Image Processing, Computer-Assisted/methods; Sodium; Sodium Isotopes; Dynamic mode decomposition; Low-rank; Neuroimaging; Single and triple quantum imaging; Sodium MRI; Sodium multi-quantum coherences, Algorithms

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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