Second malignancies in hydroxyurea and interferon‐treated Philadelphia‐negative myeloproliferative neoplasms
Copyright policy )Second malignancies in hydroxyurea and interferon‐treated Philadelphia‐negative myeloproliferative neoplasms
AbstractObjectiveIn an era of controversy in regard to ‘hydroxyurea‐leukaemogenicity’ and when interferon‐alfa2 (IFN) is being revived in the treatment of Philadelphia‐negative myeloproliferative neoplasms (MPNs), we aim in this single‐centre observational study to describe the frequencies of second malignancies in a cohort of MPN patients treated with hydroxyurea (HU) or IFN monotherapy or the combination of these agents.Patients and methodsRecords of a MPN cohort of 196 patients were reviewed, and a retrospective analysis was performed on 90 patients treated with HU, 38 patients treated with IFN and 68 patients treated with both IFN and HU. Logistic regression was used to compare frequencies in second malignancies.ResultsPatients treated with HU had a significantly higher risk of developing all second malignancies compared with patients treated with IFN [HU vs. IFN: OR of 4.01 (95%CI: 1.12–14.27, P‐value: 0.023) and HU‐IFN vs. IFN: OR 5.58 (95%CI: 1.55–20.15, P‐value: 0.004)].ConclusionWe have found an increased risk of second malignancies in MPN patients treated with HU compared with patients treated with IFN.
- University of Copenhagen Denmark
- University of Copenhagen Denmark
- Rigshospitalet Denmark
- Copenhagen University Hospital Denmark
Adult, Aged, 80 and over, Male, Myeloproliferative Disorders, Hydroxyurea/therapeutic use, Interferon-alpha/therapeutic use, Interferon-alpha, Neoplasms, Second Primary, Comorbidity, Middle Aged, Myeloproliferative Disorders/diagnosis, Young Adult, Neoplasms, 80 and over, Odds Ratio, Humans, Hydroxyurea, Female, Second Primary/diagnosis, Age of Onset, Aged, Retrospective Studies
Adult, Aged, 80 and over, Male, Myeloproliferative Disorders, Hydroxyurea/therapeutic use, Interferon-alpha/therapeutic use, Interferon-alpha, Neoplasms, Second Primary, Comorbidity, Middle Aged, Myeloproliferative Disorders/diagnosis, Young Adult, Neoplasms, 80 and over, Odds Ratio, Humans, Hydroxyurea, Female, Second Primary/diagnosis, Age of Onset, Aged, Retrospective Studies
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