Integrated urban regeneration can be considered a paradigm of modern society, which systematizes the needs of resilience of the territory with a policy aimed at improving its competitiveness, through an approach characterized by social, economic and environmental sustainability. The need for regeneration of the built environment, in particular that related to university functions, requires a specific methodological approach, which look at the complexity of the various aspects. The proposed design methodology is a response to the lack of operational tools in place, for the purpose of effective and efficient redevelopment. The case study presented in the research is related to the University Campus of Coppito, one of the three university centers of the city of L'Aquila. The study proposes a methodology to reconfigure the complex, refunctionalizing its spaces and connections, creating new spaces for social aggregation and study, technologically advanced. The innovative approach intends to pursue an integrated urban regeneration that aims to open the university center to the city and the community.