Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ HAL - Université de ...arrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
HAL - Université de Lille
Conference object . 2026
License: CC BY
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
https://doi.org/10.1007/978-3-...
Part of book or chapter of book . 2025 . Peer-reviewed
License: Springer Nature TDM
Data sources: Crossref
versions View all 2 versions
addClaim

This Research product is the result of merged Research products in OpenAIRE.

You have already added 0 works in your ORCID record related to the merged Research product.

Conditions for Cyclic Attractors for a Class of Discrete n-Dimensional Repressilators

Authors: Sun, Honglu; Folschette, Maxime; Magnin, Morgan; Tonello, Elisa;

Conditions for Cyclic Attractors for a Class of Discrete n-Dimensional Repressilators

Abstract

Repressilators are biological regulatory networks in which components interact only in terms of negative influences. They are of interest in biology, since their oscillatory behavior can inform the design of gene therapies. Although sustained oscillations are ensured in 3-dimensional repressilators, that is, in systems made of 3 genes, they do not always appear in higher dimensions, as their occurrence depends on the topology of the network and on the chosen parameters. Here we focus on discrete models, where the presence of at least one cyclic attractor is required for sustained oscillations. Even in a discrete framework, enumerating and simulating all possible models can quickly become computationally infeasible. In this paper, we provide a sufficient condition for the presence of sustained oscillations for a class of repressilators, based on the structure of their influence graphs. The condition applies in any dimension and independently of the parameters, that is, threshold labeling of the edges. We also study the coexistence of cyclic attractors and fixed points in dimension 4.

Related Organizations
Keywords

Interaction graph, Repressilators, Discrete regulatory networks, Attractors, Static analysis, [INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM]

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average