descriptionPublicationkeyboard_double_arrow_right Article 27 Jun 2018Publisher:SE Dnipropetrovsk Medical Academy of Health Ministry of UkraineJournal:Urology, volume 22 (issn: 2307-5279,

Authors: Borisov, S.A.; Kostyev, F.I.; Borisov, A.V.;

doi: 10.26641/2307-5279.22.2.2018.135700

The role of carbohydrate-protein metabolism products during acute pyelonephritis with concomitant diabetes mellitus in an experiment

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Abstract

The results of experimental work on rats are analyzed in the study, by determining the possibilities for correcting the level of glycosylation products and the state of the functional ability of proteins at an early stage of the infectious inflammatory process in the kidneys. The intensity of the formation of methylglyoxal in acute pyelonephritis complicated by concomitant diabetes is due to the development of oxidative stress, which is confirmed by an increase in the level of protein carbonyl groups in the tissues studied. The presented data allow deeper to lower the features of the pathogenetic mechanisms underlying the development and course of acute pyelonephritis complicated by diabetes mellitus, and the use of multivector drug products reduced the severity of pathological abnormalities in blood and kidney tissues to a greater extent in diabetes mellitus type II, which creates conditions to improve the morphofunctional state of the kidneys.

Keywords

гострий пієлонефрит; вуглеводно-білковий метаболізм; оксидативний стрес; цукровий діабет; перебіг; медикаментозна корекція, acute pyelonephritis; carbohydrate-protein metabolism; oxidative stress; diabetes mellitus; flow; drug correction, острый пиелонефрит; углеводно-белковый метаболизм; оксидативный стресс; сахарный диабет; течение; медикаментозная коррекция

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