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IEEE Control Systems Letters
Article . 2023 . Peer-reviewed
License: IEEE Copyright
Data sources: Crossref
https://dx.doi.org/10.48550/ar...
Article . 2022
License: arXiv Non-Exclusive Distribution
Data sources: Datacite
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Control of Multistability Through Local Sensitivity Analysis: Application to Cellular Decision-Making Networks

Authors: Moreno-Morton, Rodrigo; Franci, Alessio;

Control of Multistability Through Local Sensitivity Analysis: Application to Cellular Decision-Making Networks

Abstract

Control of multistable dynamical system has important applications, from physics to biology. Here, we attack this problem from the perspective of local sensitivity analysis. We develop sensitivity rules to control properties of continuous-time multistable dynamics with simple attractors, namely, the relative size and depth of their basins of attraction. Our parameter control signal is computationally cheap and provides counter-intuitive information about the sensitive parameters to be manipulated in an experimental setting.

Gave an in-depth discussion of and added references to the theory in Section III. Slight change of structure in Control Strategies. Slight changes to figures and discussion of example systems

Keywords

Control and Optimization, Molecular Networks (q-bio.MN), Eigenvalue and eigenfunctions, Biomolecular system, Dynamical Systems (math.DS), Control of networks, Ingénierie, informatique & technologie, FOS: Mathematics, Multistable, Lyapunov's methods, Quantitative Biology - Molecular Networks, Mathematics - Dynamical Systems, Mathematics - Optimization and Control, biomolecular systems, stability of nonlinear systems, Multistability, Manifold, Stability analyze, Engineering, computing & technology, Control and Systems Engineering, Optimization and Control (math.OC), Decisions makings, FOS: Biological sciences, Stability of nonlinear systems

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Average
Average
Green