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Revista Colombiana de Química
Article . 2022 . Peer-reviewed
License: CC BY
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https://dx.doi.org/10.60692/05...
Other literature type . 2022
Data sources: Datacite
https://dx.doi.org/10.60692/vw...
Other literature type . 2022
Data sources: Datacite
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Biological homochirality and stoichiometric network analysis: Variations on Frank’s model

التجانس البيولوجي وتحليل الشبكة المتكافئة: الاختلافات في نموذج فرانك
Authors: Jesús Ágreda; J. Andrés Montoya; Carolina Mejía;

Biological homochirality and stoichiometric network analysis: Variations on Frank’s model

Abstract

Biological homochirality is modelled using chemical reaction mechanisms that include autocatalytic and inhibition reactions as well as input and output flows. From the mathematical point of view, the differential equations associated with those mechanisms have to exhibit bistability. The search for those bifurcations can be carried out using stoichiometric network analysis. This algorithm simplifies the mathematical analysis and can be implemented in a computer programme, which can help us to analyse chemical networks. However, regardless of the reduction to linear polynomials, which is made possible by this algorithm, in some cases, the complexity and length of the polynomials involved make the analysis unfeasible. This problem has been partially solved by extending the stoichiometric matrix with rows that code the duality relations between the different reactions occurring in the network given as input. All these facts allow us to analyse 28 different network models, highlighting the basic requirements needed by a chemical mechanism to have spontaneous mirror symmetry breaking.

Related Organizations
Keywords

Origin of Life and Prebiotic Chemistry, Biological network, Organic chemistry, feedback, Homochirality, Biochemistry, Autocatalysis, homoquiralidade, Enantiomer, Homology Modeling, Systems Biology, Physics, análise de redes estequiométricas, Life Sciences, Discrete mathematics, Stoichiometry, stoichiometric network analysis, Stochasticity in Gene Regulatory Networks, Algorithm, mecanismos de reação, Chemistry, Physical chemistry, Physical Sciences, chemical reaction mechanisms, Reduction (mathematics), Bistability, mecanismos de reacción, Geometry, Quantum mechanics, Catalysis, retroalimentação, Biochemistry, Genetics and Molecular Biology, autocatalysis, FOS: Mathematics, Molecular Biology, autocatálise, autocatálisis, Protein Structure Prediction and Analysis, Astronomy and Astrophysics, Biochemical Modeling, Applied mathematics, homoquiralidad, Computer science, retroalimentación, Physics and Astronomy, Combinatorics, Duality (order theory), análisis de redes estequiométricas, Mathematics

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
Green
gold