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Publication . Article . 2018

2-Pyridone-functionalized Aza-BODIPY photosensitizer for imaging-guided sustainable phototherapy

Wanyue Xiao; Peng Wang; Changjin Ou; Xiaoyu Huang; Yunyun Tang; Meiyan Wu; Weili Si; +3 Authors
Closed Access
Published: 01 Nov 2018 Journal: Biomaterials, volume 183, pages 1-9 (issn: 0142-9612, Copyright policy )
Publisher: Elsevier BV
Abstract
To overcome irradiation-dependence of cancer phototherapy, a near infrared aza-BODIPY-based photothermogenic photosensitizer BDY with 2-Pyridone group has been synthesized for imaging-guided photothermal synergistic sustainable photodynamic therapy. Multifunctional water-soluble BDY nanoparticles (NPs), with high photothermal conversion efficiency of 35.7% and excellent singlet oxygen (1O2) generation ability, are prepared by self-assembling. The reversible transformation between 2-pyridone moiety and its endoperoxide form endows BDY with continuous 1O2 generation ability under illumination and non-illumination conditions. Simultaneously, BDY NPs exhibit excellent tumor targeting properties by enhanced permeability and retention (EPR) effect and photoacoustic imaging (PAI) ability. Furthermore, the photothermal assisted sustainable photodynamic therapy can significantly inhibit tumor growth (93.4% inhibition) with almost no side effects by intermittent laser illumination. The finding highlights that this photothermal synergistic sustainable phototherapy presents great potential for clinical applications.
Subjects by Vocabulary

Microsoft Academic Graph classification: Nanoparticle Photosensitizer Singlet oxygen chemistry.chemical_compound chemistry Photothermal therapy Photodynamic therapy medicine.medical_treatment medicine 2-Pyridone Aza-bodipy Moiety Photochemistry

Medical Subject Headings: education

Subjects

Mechanics of Materials, Biomaterials, Biophysics, Ceramics and Composites, Bioengineering

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