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Publication . Article . 2017

Restoration of immune and renal function in aged females by re-establishment of active ovarian function

Peterson, Rhett L.; Parkinson, Kate C.; Mason, Jeffrey B.;
Published: 01 Jan 2017
Publisher: CSIRO Publishing
Proper immune functioning is necessary to maximize reproductive success. In addition, age-associated uremia in women is often associated with hypothalamic­–pituitary–gonadal dysfunction. In the present experiments, we tested immune and renal function to determine if exposure of postreproductive mice to young, reproductively cycling ovaries would influence non-reproductive physiological functions. Control female CBA/J mice were evaluated at 6, 13 and 16 months of age. Additional mice received new (60-day-old) ovaries at 12 months of age and were evaluated at 16 months of age. Consequently, 6-month-old control mice and 16-month-old recipient mice both possessed 6-month-old ovaries and were reproductively cycling. A significant age-related decline in immune function (T-cell subset analysis) was found in 16-month-old mice, but was improved 64% by ovarian transplantation. Renal function (blood urea nitrogen : creatinine ratio) was also decreased with aging, but ovarian transplantation restored function to levels found in 6-month-old mice. In summary, we have shown that immune and renal function, which are negatively influenced by aging, can be positively influenced or restored by re-establishment of active ovarian function in aged female mice. These findings provide a strong incentive for further investigation of the positive influence of young ovaries on restoration of health in postreproductive females.
Subjects by Vocabulary

Microsoft Academic Graph classification: Endocrinology medicine.medical_specialty medicine Menopause medicine.disease Internal medicine Ovary medicine.anatomical_structure Creatinine chemistry.chemical_compound chemistry Reproductive technology Blood urea nitrogen Renal function Biology Renal physiology Uremia


Developmental Biology, Endocrinology, Genetics, Molecular Biology, Animal Science and Zoology, Reproductive Medicine, Biotechnology

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