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RSC Medicinal Chemistry

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The war on hTG2: warhead optimization in small molecule human tissue transglutaminase inhibitors

Name: The war on hTG2: warhead optimization in small molecule human tissue transglutaminase inhibitors
Keywords: Pharmacology, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Biochemistry

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2023Royal Society of Chemistry (RSC)RSC Medicinal Chemistry, volume 14, pages 277-298 (eissn: 2632-8682,

Authors: Lavleen Mader; Sarah K. I. Watt; Harish R. Iyer; Linh Nguyen; Harpreet Kaur; Jeffrey W. Keillor;

doi: 10.1039/d2md00378c

The war on hTG2: warhead optimization in small molecule human tissue transglutaminase inhibitors

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Abstract

This systematic structure–activity relationship study provides key insights into warhead design and application for optimizing efficiency, selectivity, and pharmacokinetic stability of hTG2 inhibitors.

Keywords

Pharmacology, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Biochemistry

1 Research products, page 1 of 1

CCDC 2213069: Experimental Crystal Structure Determination
2023IsSupplementedBy

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average

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NSERC, CIHR

The war on hTG2: warhead optimization in small molecule human tissue transglutaminase inhibitors

The war on hTG2: warhead optimization in small molecule human tissue transglutaminase inhibitors

1 Research products, page 1 of 1

CCDC 2213069: Experimental Crystal Structure Determination