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Publication . Article . 2017

pH-Triggered and Enhanced Simultaneous Photodynamic and Photothermal Therapy Guided by Photoacoustic and Photothermal Imaging

Qianyun Tang; Wanyue Xiao; Chuhan Huang; Weili Si; Jinjun Shao; Wei Huang; Peng Chen; +2 Authors
Published: 07 Jun 2017 Journal: Chemistry of Materials, volume 29, pages 5,216-5,224 (issn: 0897-4756, eissn: 1520-5002, Copyright policy )
Publisher: American Chemical Society (ACS)
Abstract
Developing smart photosensitizers sensitively responding to tumor-specific signals for reduced side effects and enhanced anticancer efficacy is a major challenge for tumor phototherapy. Herein, a pH-sensitive photosensitizer has been synthesized through introducing a pH-sensitive receptor (dimethylaminophenyl unit) onto the aza-BODIPY core (abbreviated as NAB). Through enveloping hydrophobic NAB with amphiphilic DSPE-mPEG2000, NAB nanoparticles (NPs, diameter ∼ 30 nm) with strong near-infrared absorption (∼792 nm) are obtained. NAB NPs can be activated in weak acidic environment to give high rate of reactive oxygen species (ROS) generation and enhanced photothermal effect. NAB NPs can selectively accumulate in the lysosomes of tumor cells and subsequently activate under the acidic microenvironment of lysosome (pH 5.0) to produce ROS for photodynamic therapy, due to switch-off of the photoinduced electron transfer (PET) pathway. In vivo, pH-enhanced photoacoustic imaging (PAI) and photothermal imaging (PTI...
Subjects by Vocabulary

Microsoft Academic Graph classification: Photothermal therapy Photothermal effect Photoinduced electron transfer Reactive oxygen species chemistry.chemical_classification chemistry Photosensitizer Nanoparticle In vivo Photochemistry Materials science Photodynamic therapy medicine.medical_treatment medicine

Subjects

Materials Chemistry, General Chemical Engineering, General Chemistry

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