publication . Article . 2014

n Vitro Immunomodulatory Effect of R10 Fraction of Garlic on Viability and Production of TNF-? in CD8+ T Cells

T. Ghazanfari; H. Rashidi; Sh. Jalaei; P. Alijani;
Open Access Persian
  • Published: 01 Jan 2014 Journal: Scientific Journal of Hamadan University of Medical Sciences (issn: 1025-4285, eissn: 2251-662X, Copyright policy)
  • Publisher: Hamadan University of Medical Sciences
Abstract
Introduction & Objective: -cells, especially CD8+ T lymphocytes are the most important cells in anti-tumor response. Previously R10 fraction of garlic extract was reported as an immuno-modulator which induced an effective cellular immunity and Th1 responses. In this study the in vitro immunomodulatory effect of R10 on CD8+ T cells viability and production of TNF-? were evaluated. Materials & Methods: In this experimental study, using monoclonal antibodies attached to magnetic beads with isolating columns by magnetic bead method, CD8+ T cells from spleen cells of Balb/C mice were isolated. R10 fraction based on molecular weight was prepared using Ultra filtration...
Subjects
free text keywords: CD8+ T cells, Cytokines, Garlic, R10 Fraction / Viability, R10 Fraction, Viability, Medicine (General), R5-920
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