publication . Article . 2005

Inducible nitric oxide synthase links NF-κB to PGE2 in polyunsaturated fatty acid altered fibroblast in-vitro wound healing

Turek John J; Jia Yi;
Open Access English
  • Published: 01 Jul 2005 Journal: Lipids in Health and Disease (issn: 1476-511X, Copyright policy)
  • Publisher: BMC
<p>Abstract</p> <p>Background</p> <p>This study investigated mechanisms of altered fibroblast collagen production induced by polyunsaturated fatty acids. 3T3-Swiss fibroblasts were grown in medium containing either eicosapentaenoic or arachidonic acid. The effects of nuclear factor-kappaB activation by lipopolysaccharide on inducible nitric oxide synthase, nitric oxide, prostaglandin E<sub>2</sub>, collagen production, and <it>in-vitro </it>wound healing were studied.</p> <p>Results</p> <p>Eicosapentaenoic acid treated cells produced less prostaglandin E<sub>2 </sub>but had increased inducible nitric oxide synthase expression, nitric oxide production, collagen f...
free text keywords: Nutritional diseases. Deficiency diseases, RC620-627
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