publication . Article . 2017

Intravenous Infusion of Bone Marrow–Derived Mesenchymal Stem Cells Reduces Erectile Dysfunction Following Cavernous Nerve Injury in Rats

Matsuda, Yohei; Sasaki, Masanori; Kataoka-Sasaki, Yuko; Takayanagi, Akio; Kobayashi, Ko; Oka, Shinichi; Nakazaki, Masahito; Masumori, Naoya; Kocsis, Jeffery D.; Honmou, Osamu;
Open Access
  • Published: 01 Dec 2017 Journal: Sexual Medicine, volume 6, pages 49-57 (issn: 2050-1161, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Introduction: Intravenous preload (delivered before cavernous nerve [CN] injury) of bone marrow–derived mesenchymal stem cells (MSCs) can prevent or decrease postoperative erectile dysfunction (J Sex Med 2015;12:1713–1721). In the present study, the potential therapeutic effects of intravenously administered MSCs on postoperative erectile dysfunction were evaluated in a rat model of CN injury. Methods: Male Sprague-Dawley rats were randomized into 2 groups after electric CN injury. Intravenous infusion of bone marrow–derived MSCs (1.0 × 106 cells in Dulbecco's modified Eagle's medium 1 mL) or vehicle (Dulbecco's modified Eagle's medium 1 mL) was performed 3 hour...
Subjects
free text keywords: Urology, Behavioral Neuroscience, Reproductive Medicine, Dermatology, medicine.medical_specialty, medicine, Therapeutic effect, Erectile dysfunction, medicine.disease, Nerve injury, medicine.symptom, Mesenchymal stem cell, Surgery, Area under the curve, Smooth muscle atrophy, Blood pressure, business.industry, business, Bone marrow, medicine.anatomical_structure, Cavernous Nerve Injury, R, Other systems of medicine, RZ201-999
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publication . Article . 2017

Intravenous Infusion of Bone Marrow–Derived Mesenchymal Stem Cells Reduces Erectile Dysfunction Following Cavernous Nerve Injury in Rats

Matsuda, Yohei; Sasaki, Masanori; Kataoka-Sasaki, Yuko; Takayanagi, Akio; Kobayashi, Ko; Oka, Shinichi; Nakazaki, Masahito; Masumori, Naoya; Kocsis, Jeffery D.; Honmou, Osamu;