publication . Other literature type . Article . 2018

Fungicidal PMMA-Undecylenic Acid Composites.

Milica Petrović; Debora Bonvin; Heinrich Hofmann; Marijana Mionić Ebersold;
Open Access
  • Published: 08 Jan 2018
  • Publisher: MDPI AG
  • Country: Switzerland
Undecylenic acid (UA), known as antifungal agent, still cannot be used to efficiently modify commercial dental materials in such a way that this affects Candida. Actually, issues with Candida infections and fungal resistance compromise the use of Poly(methyl-methacrylate) (PMMA) as dental material. The challenge remains to turn PMMA into an antifugal material, which can ideally affect both sessile (attached) and planktonic (free-floating) Candida cells. We aimed to tackle this challenge by designing PMMA-UA composites with different UA concentrations (3–12%). We studied their physico-chemical properties, the antifungal effect on Candida and the cytotoxicity towa...
free text keywords: Physical and Theoretical Chemistry, Inorganic Chemistry, Organic Chemistry, Spectroscopy, Molecular Biology, Catalysis, General Medicine, Computer Science Applications, undecylenic acid, PMMA, antifungal, fungicidal, anti-Candida, Candida albicans, Biology (General), QH301-705.5, Chemistry, QD1-999, Article
42 references, page 1 of 3

Denning, D.W.; Bromley, M.J. How to bolster the antifungal pipeline. Science 2015, 347, 1414-1416. [CrossRef]

Fungal Infections. Sci. Transl. Med. 2012, 4, 165rv13. [CrossRef] [PubMed]

27 October 2017).

Candida albicans biofilms. Nat. Rev. Microbiol. 2017. [CrossRef] [PubMed]

Mayer, F.L.; Wilson, D.; Hube, B. Candida albicans pathogenicity mechanisms. Virulence 2013, 4, 119-128. [OpenAIRE]

Nobile, C.J.; Johnson, A.D. Candida albicans Biofilms and Human Disease. Annu. Rev. Microbiol. 2015, 69, [OpenAIRE]

71-92. [CrossRef] [PubMed]

Poulain, D. Candida albicans, plasticity and pathogenesis. Crit. Rev. Microbiol. 2015, 41, 208-217. [CrossRef] [OpenAIRE]

albicans Virulence and Omics Approaches on Host-Pathogen Interaction: A Review. Int. J. Mol. Sci. 2016,

17, 1643. [CrossRef] [PubMed]

9. De Toledo, L.G.; Ramos, M.A.D.S.; Spósito, L.; Castilho, E.M.; Pavan, F.R.; Lopes, É.D.O.; Zocolo, G.J.; Silva, F.A.N.; Soares, T.H.; dos Santos, A.G.; et al. Essential Oil of Cymbopogon nardus (L.) Rendle: A Strategy to Combat Fungal Infections Caused by Candida Species. Int. J. Mol. Sci. 2016, 17, 1252. [CrossRef] [PubMed]

10. Jacobsen, I.D.; Hube, B. Candida albicans morphology: Still in focus. Expert Rev. Anti-Infect. Ther. 2017, 15, 327-330. [CrossRef] [PubMed] [OpenAIRE]

11. Koo, H.; Allan, R.N.; Howlin, R.P.; Stoodley, P.; Hall-Stoodley, L. Targeting microbial biofilms: Current and prospective therapeutic strategies. Nat. Rev. Microbiol. 2017. [CrossRef] [PubMed] [OpenAIRE]

12. Perfect, J.R. The antifungal pipeline: A reality check. Nat. Rev. Drug Discov. 2017, 16, 603-616. [CrossRef] [PubMed] [OpenAIRE]

13. Vila, T.; Romo, J.A.; Pierce, C.G.; McHardy, S.F.; Saville, S.P.; Lopez-Ribot, J.L. Targeting Candida albicans filamentation for antifungal drug development. Virulence 2017, 8, 150-158. [CrossRef] [PubMed]

42 references, page 1 of 3
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue