publication . Other literature type . Article . 2015

Oxidative stress and Parkinson’s disease

Javier eBlesa; Javier eBlesa; Javier eBlesa; Ines eTrigo-Damas; Ines eTrigo-Damas; Anna eQuiroga-Varela; Vernice Ruffin Jackson-Lewis;
Open Access
  • Published: 01 Jul 2015
  • Publisher: Frontiers Media SA
Abstract
Parkinson disease is a chronic, progressive neurological disease that is associated with a loss of dopaminergic neurons in the substantia nigra of the brain. The molecular mechanisms underlying the loss of these neurons still remain elusive. Oxidative stress is thought to play an important role in dopaminergic neurotoxicity. Complex I deficiencies of the respiratory chain account for the majority of unfavorable neuronal degeneration in Parkinson’s Disease. Environmental factors, such as neurotoxins, insecticides like rotenone, pesticides like Paraquat, dopamine itself and genetic mutations in Parkinson’s Disease related proteins contribute to mitochondrial dysfu...
Persistent Identifiers
Subjects
Medical Subject Headings: nervous system
free text keywords: Neuroanatomy, mitochondrial dysfunction, dopamine, neuroinflammation, Parkinson disease, oxidative stress, Mini Review, Neurodegeneration, medicine.disease, medicine, Substantia nigra, Respiratory chain, medicine.disease_cause, Neuroscience, Parkinson's disease, business.industry, business, Dopaminergic, Pars compacta, Neurotoxicity, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:RC321-571, lcsh:Human anatomy, lcsh:QM1-695
Related Organizations
140 references, page 1 of 10

Amo T.Saiki S.Sawayama T.Sato S.Hattori N. (2014). Detailed analysis of mitochondrial respiratory chain defects caused by loss of PINK1.Neurosci. Lett. 580 37–40. 10.1016/j.neulet.2014.07.045 25092611 [OpenAIRE] [PubMed] [DOI]

Amo T.Sato S.Saiki S.Wolf A. M.Toyomizu M.Gautier C. A. (2011). Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects. Neurobiol. Dis. 41 111–118. 10.1016/j.nbd.2010.08.027 20817094 [PubMed] [DOI]

Ares-Santos S.Granado N.Espadas I.Martinez-Murillo R.Moratalla R. (2014). Methamphetamine causes degeneration of dopamine cell bodies and terminals of the nigrostriatal pathway evidenced by silver staining. Neuropsychopharmacology 39 1066–1080. 10.1038/npp.2013.307 24169803 [OpenAIRE] [PubMed] [DOI]

Asanuma M.Miyazaki I.Ogawa N. (2003). Dopamine- or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson’s disease. Neurotox. Res. 5 165–176. 10.1007/BF03033137 12835121 [OpenAIRE] [PubMed] [DOI]

Austin S. A.Floden A. M.Murphy E. J.Combs C. K. (2006). Alpha-synuclein expression modulates microglial activation phenotype. J. Neurosci. 26 10558–10563. 10.1523/JNEUROSCI.1799-06.2006 17035541 [OpenAIRE] [PubMed] [DOI]

Bandopadhyay R.Kingsbury A. E.Cookson M. R.Reid A. R.Evans I. M.Hope A. D. (2004). The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson’s disease. Brain 127 420–430. 10.1093/brain/awh054 14662519 [OpenAIRE] [PubMed] [DOI]

Barcia C.Fernández Barreiro A.Poza M.Herrero M.-T. T.Fernandez Barreiro A. (2003). Parkinson’s disease and inflammatory changes. Neurotox. Res. 5 411–418. 10.1007/BF03033170 14715444 [PubMed] [DOI]

Barcia C.Ros C. M.Carrillo M. A.Ros F.Gomez A.de Pablos V. (2009). Increase of secondary processes of microglial and astroglial cells after MPTP-induced degeneration in substantia nigra pars compacta of non human primates. J. Neural Transm. Suppl. 73 253–258. 10.1007/978-3-211-92660-4_20 20411783 [OpenAIRE] [PubMed] [DOI]

Barcia C.Sánchez Bahillo A.Fernández-Villalba E.Bautista V.Poza Y Poza M.Fernández-Barreiro A. (2004). Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure. Glia 46 402–409. 10.1002/glia.20015 15095370 [OpenAIRE] [PubMed] [DOI]

Beach T. G.Sue L. I.Walker D. G.Lue L. F.Connor D. J.Caviness J. N. (2007). Marked microglial reaction in normal aging human substantia nigra: correlation with extraneuronal neuromelanin pigment deposits. Acta Neuropathol. 114 419–424. 10.1007/s00401-007-0250-255 17639428 [OpenAIRE] [PubMed] [DOI]

Belluzzi E.Bisaglia M.Lazzarini E.Tabares L. C.Beltramini M.Bubacco L. (2012). Human SOD2 modification by dopamine quinones affects enzymatic activity by promoting its aggregation: possible implications for Parkinson’s disease. PLoS ONE 7:e38026 10.1371/journal.pone.0038026 [OpenAIRE] [DOI]

Berman S. B.Hastings T. G. (1999). Dopamine oxidation alters mitochondri al respiration and induces permeability transition in brain mitochondria: implications for Parkinson’s disease. J. Neurochem. 73 1127–1137. 10.1046/j.1471-4159.1999.0731127.x 10461904 [OpenAIRE] [PubMed] [DOI]

Betarbet R.Sherer T. B.MacKenzie G.Garcia-Osuna M.Panov A. V.Greenamyre J. T. (2000). Chronic systemic pesticide exposure reproduces features of Parkinson’s disease. Nat. Neurosci. 3 1301–1306. 10.1038/81834 11100151 [OpenAIRE] [PubMed] [DOI]

Bian M.Liu J.Hong X.Yu M.Huang Y.Sheng Z. (2012). Overexpression of parkin ameliorates dopaminergic neurodegeneration induced by 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. PLoS ONE 7:e39953 10.1371/journal.pone.0039953 [OpenAIRE] [DOI]

Blandini F.Nappi G.Greenamyre J. T. (1998). Quantitative study of mitochondrial complex I in platelets of parkinsonian patients. Mov. Disord. 13 11–15. 10.1002/mds.870130106 9452319 [OpenAIRE] [PubMed] [DOI]

140 references, page 1 of 10
Related research
Abstract
Parkinson disease is a chronic, progressive neurological disease that is associated with a loss of dopaminergic neurons in the substantia nigra of the brain. The molecular mechanisms underlying the loss of these neurons still remain elusive. Oxidative stress is thought to play an important role in dopaminergic neurotoxicity. Complex I deficiencies of the respiratory chain account for the majority of unfavorable neuronal degeneration in Parkinson’s Disease. Environmental factors, such as neurotoxins, insecticides like rotenone, pesticides like Paraquat, dopamine itself and genetic mutations in Parkinson’s Disease related proteins contribute to mitochondrial dysfu...
Persistent Identifiers
Subjects
Medical Subject Headings: nervous system
free text keywords: Neuroanatomy, mitochondrial dysfunction, dopamine, neuroinflammation, Parkinson disease, oxidative stress, Mini Review, Neurodegeneration, medicine.disease, medicine, Substantia nigra, Respiratory chain, medicine.disease_cause, Neuroscience, Parkinson's disease, business.industry, business, Dopaminergic, Pars compacta, Neurotoxicity, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:RC321-571, lcsh:Human anatomy, lcsh:QM1-695
Related Organizations
140 references, page 1 of 10

Amo T.Saiki S.Sawayama T.Sato S.Hattori N. (2014). Detailed analysis of mitochondrial respiratory chain defects caused by loss of PINK1.Neurosci. Lett. 580 37–40. 10.1016/j.neulet.2014.07.045 25092611 [OpenAIRE] [PubMed] [DOI]

Amo T.Sato S.Saiki S.Wolf A. M.Toyomizu M.Gautier C. A. (2011). Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects. Neurobiol. Dis. 41 111–118. 10.1016/j.nbd.2010.08.027 20817094 [PubMed] [DOI]

Ares-Santos S.Granado N.Espadas I.Martinez-Murillo R.Moratalla R. (2014). Methamphetamine causes degeneration of dopamine cell bodies and terminals of the nigrostriatal pathway evidenced by silver staining. Neuropsychopharmacology 39 1066–1080. 10.1038/npp.2013.307 24169803 [OpenAIRE] [PubMed] [DOI]

Asanuma M.Miyazaki I.Ogawa N. (2003). Dopamine- or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson’s disease. Neurotox. Res. 5 165–176. 10.1007/BF03033137 12835121 [OpenAIRE] [PubMed] [DOI]

Austin S. A.Floden A. M.Murphy E. J.Combs C. K. (2006). Alpha-synuclein expression modulates microglial activation phenotype. J. Neurosci. 26 10558–10563. 10.1523/JNEUROSCI.1799-06.2006 17035541 [OpenAIRE] [PubMed] [DOI]

Bandopadhyay R.Kingsbury A. E.Cookson M. R.Reid A. R.Evans I. M.Hope A. D. (2004). The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson’s disease. Brain 127 420–430. 10.1093/brain/awh054 14662519 [OpenAIRE] [PubMed] [DOI]

Barcia C.Fernández Barreiro A.Poza M.Herrero M.-T. T.Fernandez Barreiro A. (2003). Parkinson’s disease and inflammatory changes. Neurotox. Res. 5 411–418. 10.1007/BF03033170 14715444 [PubMed] [DOI]

Barcia C.Ros C. M.Carrillo M. A.Ros F.Gomez A.de Pablos V. (2009). Increase of secondary processes of microglial and astroglial cells after MPTP-induced degeneration in substantia nigra pars compacta of non human primates. J. Neural Transm. Suppl. 73 253–258. 10.1007/978-3-211-92660-4_20 20411783 [OpenAIRE] [PubMed] [DOI]

Barcia C.Sánchez Bahillo A.Fernández-Villalba E.Bautista V.Poza Y Poza M.Fernández-Barreiro A. (2004). Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure. Glia 46 402–409. 10.1002/glia.20015 15095370 [OpenAIRE] [PubMed] [DOI]

Beach T. G.Sue L. I.Walker D. G.Lue L. F.Connor D. J.Caviness J. N. (2007). Marked microglial reaction in normal aging human substantia nigra: correlation with extraneuronal neuromelanin pigment deposits. Acta Neuropathol. 114 419–424. 10.1007/s00401-007-0250-255 17639428 [OpenAIRE] [PubMed] [DOI]

Belluzzi E.Bisaglia M.Lazzarini E.Tabares L. C.Beltramini M.Bubacco L. (2012). Human SOD2 modification by dopamine quinones affects enzymatic activity by promoting its aggregation: possible implications for Parkinson’s disease. PLoS ONE 7:e38026 10.1371/journal.pone.0038026 [OpenAIRE] [DOI]

Berman S. B.Hastings T. G. (1999). Dopamine oxidation alters mitochondri al respiration and induces permeability transition in brain mitochondria: implications for Parkinson’s disease. J. Neurochem. 73 1127–1137. 10.1046/j.1471-4159.1999.0731127.x 10461904 [OpenAIRE] [PubMed] [DOI]

Betarbet R.Sherer T. B.MacKenzie G.Garcia-Osuna M.Panov A. V.Greenamyre J. T. (2000). Chronic systemic pesticide exposure reproduces features of Parkinson’s disease. Nat. Neurosci. 3 1301–1306. 10.1038/81834 11100151 [OpenAIRE] [PubMed] [DOI]

Bian M.Liu J.Hong X.Yu M.Huang Y.Sheng Z. (2012). Overexpression of parkin ameliorates dopaminergic neurodegeneration induced by 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. PLoS ONE 7:e39953 10.1371/journal.pone.0039953 [OpenAIRE] [DOI]

Blandini F.Nappi G.Greenamyre J. T. (1998). Quantitative study of mitochondrial complex I in platelets of parkinsonian patients. Mov. Disord. 13 11–15. 10.1002/mds.870130106 9452319 [OpenAIRE] [PubMed] [DOI]

140 references, page 1 of 10
Related research
Any information missing or wrong?Report an Issue