13 reasons why the brain is susceptible to oxidative stress

Article English OPEN
Cobley, James Nathan ; Fiorello, Maria Luisa ; Bailey, Damian Miles (2018)
  • Publisher: Elsevier
  • Journal: Redox Biology, volume 15, pages 490-503 (issn: 2213-2317, eissn: 2213-2317)
  • Related identifiers: doi: 10.1016/j.redox.2018.01.008, pmc: PMC5881419
  • Subject: Redox signalling | Review Article | R5-920 | Mitochondria | Medicine (General) | Neurodegeneration | Brain | Oxidative stress | Biology (General) | QH301-705.5

The human brain consumes 20% of the total basal oxygen (O2) budget to support ATP intensive neuronal activity. Without sufficient O2 to support ATP demands, neuronal activity fails, such that, even transient ischemia is neurodegenerative. While the essentiality of O2 to... View more
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